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Role of Microsatellite Instability as Pan-Cancer Agnostic Marker of Solid Tumours in Personalized Medicine
IntroductionMicrosatellite instability (MSI) is defined as accumulation of mutations in short repeated DNA sequences (1 to 9 nucleotides) that occurs...
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DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data
BackgroundDNA mismatch repair deficiency (dMMR) testing is crucial for detection of microsatellite unstable (MSI) tumors. MSI is detected by aberrant...
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MSINGB: A Novel Computational Method Based on NGBoost for Identifying Microsatellite Instability Status from Tumor Mutation Annotation Data
AbstractMicrosatellite instability (MSI), a vital mutator phenotype caused by DNA mismatch repair deficiency, is frequently observed in several...
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Genomic Instability
Maintenance of genome stability is vital for human health, and it is of particular importance in ageing. Genome stability is regulated by multiple...
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Entamoeba histolytica and Probable Effect on Production Microsatellite Instability in Colorectal Cancer
The mortality rate of Entamoeba histolytica is still high and approximately 100,000 per year. Environmental factors and different pathogens can cause...
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Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer
Background and aimsRecent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To...
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Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer
Colorectal cancer has one of the highest mortality rates among malignant tumors, and most patients with non-microsatellite instability-high (MSI-H)...
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Loss of fragile WWOX gene leads to senescence escape and genome instability
Induction of DNA damage response (DDR) to ensure accurate duplication of genetic information is crucial for maintaining genome integrity during DNA...
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Fine scale population genetic structure of Euphlyctis karaavali (Amphibia: Anura) using newly developed microsatellite markers
Amphibian genus Euphlyctis Fitzinger, 1843 from the family Dicroglossidae (Anderson, 1871) contains eight species. Euphlyctis karaavali , an edible...
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Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 or its ligand (PD-1/L1) have expanded the treatment landscape against...
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Study on the characteristics of genetic diversity of different populations of Guizhou endemic plant Rhododendron pudingense based on microsatellite markers
BackgroundRhododendron pudingense , firstly discovered in Puding county of Guizhou province in 2020, have adapted to living in rocky fissure habitat,...
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RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases
Many incurable neurological and neuromuscular diseases are caused by microsatellite expansions consisted of 3–6 nucleotide repeat units. The expanded...
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The reckoning of chromosomal instability: past, present, future
Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified,...
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Comparison of microsatellite distribution in the genomes of Pteropus vampyrus and Miniopterus natalensis (Chiroptera)
BackgroundMicrosatellites are a ubiquitous occurrence in prokaryotic and eukaryotic genomes. Microsatellites have become one of the most popular...
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Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer
AbstractPersonalization of gastric cancer (GC) treatment is an urgent problem because of the clinical heterogeneity and aggressive course of the...
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Recent amplification of microsatellite-associated miniature inverted-repeat transposable elements in the pineapple genome
BackgroundMiniature inverted-repeat transposable elements (MITEs) are non-autonomous DNA transposable elements that play important roles in genome...
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Patch-Based Coupled Attention Network to Predict MSI Status in Colon Cancer
Identifying and diagnosing key markers from WSI images is the key to accurate diagnosis and treatment of colon cancer (CC). However, how to extract...
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The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil
The epigenetic modifier histone deacetylase-2 (HDAC2) is frequently dysregulated in colon cancer cells. Microsatellite instability (MSI), an...
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Tools used to assay genomic instability in cancers and cancer meiomitosis
Genomic instability is a defining characteristic of cancer and the analysis of DNA damage at the chromosome level is a crucial part of the study of...
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Genome-wide characterization of microsatellite DNA in fishes: survey and analysis of their abundance and frequency in genome-specific regions
BackgroundMicrosatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene...
