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Next-Generation Sequencing: ForenSeq™ DNA Signature Prep Kit with the Illumina MiSeq FGx
Sequencing forensic DNA samples that are amplified and prepared with the ForenSeq™ DNA Signature Prep Kit allows for the simultaneous targeting of...
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A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo
The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with...
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Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening
T cell receptor (TCR) gene therapy is a potent form of cellular immunotherapy in which patient T cells are genetically engineered to express TCRs...
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DNA Sequencing Technologies and DNA Barcoding
DNA barcodes are short, standardized DNA segments that geneticists can use to identify all living taxa. On the other hand, DNA barcoding identifies...
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Population genetic analyses of Eastern Chinese Han nationality using ForenSeq™ DNA Signature Prep Kit
Currently, the most commonly used method for human identification and kinship analysis in forensic genetics is the detection of length polymorphism...
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Next-generation sequencing technology: a boon to agriculture
Next-generation sequencing (NGS) is a massively parallel sequencing technology that has revolutionized genomic research. The goal of genomics is...
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Characterization of 58 STRs and 94 SNPs with the ForenSeq™ DNA signature prep kit in Mexican-Mestizos from the Monterrey city (Northeast, Mexico)
BackgroundSTR allele frequency databases from populations are necessary to take full advantage of the increased power of discrimination offered by...
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Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites
Here we present an approach that combines a clustered regularly interspaced short palindromic repeats (CRISPR) system that simultaneously targets...
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Genome-Wide Expression Analysis of Genes Involved in Somatic Embryogenesis
Genome-wide expression analysis is an important tool for identifying and analysing genes involved in various biological processes, including cell...
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Massively parallel phenoty** of coding variants in cancer with Perturb-seq
Genome sequencing studies have identified millions of somatic variants in cancer, but it remains challenging to predict the phenotypic impact of...
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Next-Generation Sequencing in Medicinal Plants: Recent Progress, Opportunities, and Challenges
Medicinal plants have a significant role in human health care since the development of medicine. Plants that yield phytopharmaceuticals have produced...
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Massively parallel single-cell mitochondrial DNA genoty** and chromatin profiling
Natural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships among cells. mtDNA can be profiled along with measures of...
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Role of Next-Generation Sequencing (NGS) in Understanding the Microbial Diversity
Microbes constitute a major part of earth’s biological diversity and act as a key player by playing an important role in our day-to-day life....
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RNA Sequencing (RNA-seq)
RNA sequencing (or popularly known as RNA-seq) or whole transcriptome shortgun sequencing (WTSS) is a useful next-generation sequencing (NGS)...
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Mitochondrial point heteroplasmy: insights from deep-sequencing of human replicate samples
BackgroundHuman mitochondrial heteroplasmy is an extensively investigated phenomenon in the context of medical diagnostics, forensic identification...
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Concordance study on Y-STRs ty** between SeqStudio™ genetic analyzer for HID and MiSeq™ FGx forensic genomics system
BackgroundMassively Parallel Sequencing (MPS) allowed an increased number of information to be retrieved from short tandem repeat (STR) analysis,...
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Whole-Genome Sequencing of Plants: Past, Present, and Future
Advances in analytical chemistry, as well as the constant introduction of novel analytical chemistry approaches, are altering genomics at a higher...
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Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Gene expression is regulated by multiple epigenetic mechanisms, which are coordinated in development and disease. However, current multiomics methods...
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An anti-influenza combined therapy assessed by single cell RNA-sequencing
Influenza makes millions of people ill every year, placing a large burden on the healthcare system and the economy. To develop a treatment against...
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Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing
Cell atlas projects and high-throughput perturbation screens require single-cell sequencing at a scale that is challenging with current technology....
