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RNA-seq analysis reveals narrow differential gene expression in MEP and MVA pathways responsible for phytochemical divergence in extreme genotypes of Thymus daenensis Celak
BackgroundHere, we investigated the underlying transcriptional-level evidence behind phytochemical differences between two metabolically extreme...
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Investigation of spirooxindole-pyrrolidine derivatives as acetylcholinesterase inhibitors using molecular docking/dynamics simulations, bioisosteric replacement, MEP, and ADME/Tox properties
Acetylcholinesterase is used as a key target in the treatment of Alzheimer's disease. Recently, a series of new spirooxindolepyrrolidine derivatives...
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Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway
Sclareol, an antifungal specialized metabolite produced by clary sage, Salvia sclarea , is the starting plant natural molecule used for the...
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TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster
AbstractThe Drosophila TTK protein is involved in the processes of cell differentiation and is represented by two isoforms, TTK69 and TTK88, which...
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The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria
BackgroundIsoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or...
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Comparative analysis of biomass, ethrel elicitation, light induced differential MVA/MEP pathway gene expression and andrographolide production in adventitious root cultures of Andrographis paniculata (Burm. F.) Nees
Andrographis paniculata (Burm. F.) Nees is a rich source of biologically active andrographolide and other diterpene lactone compounds. The in vitro...
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The non-mevalonate pathway requires a delicate balance of intermediates to maximize terpene production
AbstractTerpenes are valuable industrial chemicals whose demands are increasingly being met by bioengineering microbes such as E. coli . Although the...
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YGL3 Encoding an IPP and DMAPP Synthase Interacts with OsPIL11 to Regulate Chloroplast Development in Rice
As the source of isoprenoid precursors, the plastidial methylerythritol phosphate (MEP) pathway plays an essential role in plant development. Here,...
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Evidence for Methylerythritol Pathway (MEP) Contributions to Zerumbone Biosynthesis as Revealed by Expression Analysis of Regulatory Genes and Metabolic Inhibitors Studies
Sesquiterpenoid Zerumbone, the principal secondary metabolite in Zingiber zerumbet Smith, has been identified as the putative molecule conferring...
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Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
Edible mushrooms have now been suggested as promising sources of biological functional ingredients and are the subject of the most recent nutrition...
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Isolation of 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase (ApHDR) gene of methyl erythritol diphosphate (MEP) pathway, in silico analysis and differential tissue specific ApHDR expression in Andrographis paniculata (Burm. f) Nees
The full length Andrographis paniculate 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase ( ApHDR ) gene of MEP pathway was isolated for the first...
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Engineering plant family TPS into cyanobacterial host for terpenoids production
Terpenoids are synthesized naturally by plants as secondary metabolites, and are diverse and complex in structure with multiple applications in...
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Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation
The myoepithelial (MEP) lineage of human breast comprises bipotent and multipotent progenitors in ducts and terminal duct lobular units (TDLUs). We...
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Precise motor map** with transcranial magnetic stimulation
We describe a routine to precisely localize cortical muscle representations within the primary motor cortex with transcranial magnetic stimulation...
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The SlMYC1-TOR Module Regulates Trichome Formation and Terpene Biosynthesis in Tomatoes (Solanum lycopersicum L.)
Trichomes, which are special structures on the surfaces of plants, play an important role in plant defense. Trichomes in tomatoes are composed of...
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Dynamics of annatto pigment synthesis and accumulation in seeds of Bixa orellana L. revealed by integrated chemical, anatomical, and RNA-Seq analyses
Bixin is a commercially valuable apocarotenoid pigment found in the seed aril of Bixa orellana . The dynamics and regulation of its biosynthesis and...
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Protective effect of bone morphogenetic protein-7 induced differentiation of bone marrow mesenchymal stem cells in rat with acute spinal cord injury
The principal aim of present study was to assess the therapeutic efficacy of bone morphogenetic protein-7 (BMP-7) induced differentiation of bone...
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Sucrose Induced HMGR to Promote Ginsenoside Biosynthesis in the Growth of Wild Cultivated Ginseng (Panax ginseng)
Wild cultivated ginseng is considered to be of higher quality than field-cultivated ginseng. Many active constituents of wild cultivated ginseng,...
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Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module
Chloroplasts are not only critical photosynthesis sites in plants, but they also participate in plastidial retrograde signaling in response to...
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The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds
BackgroundDeoxyxylulose 5-phosphate synthase (DXS) and deoxyxylulose 5-phosphate reductoisomerase (DXR) are the enzymes that catalyze the first two...
