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Biosensor-based high-throughput screening enabled efficient adipic acid production
AbstractAdipic acid is an industrially important chemical, but the current approach to synthesize it can be of serious pollution to the environment....
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Programming adaptive laboratory evolution of 4-hydroxyisoleucine production driven by a lysine biosensor in Corynebacterium glutamicum
4-Hydroxyisoleucine (4-HIL) is a promising drug for treating diabetes. In our previous study, 4-HIL was synthesized from self-produced L-isoleucine...
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Beyond rational—biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes
BackgroundIn contrast to modern rational metabolic engineering, classical strain development strongly relies on random mutagenesis and screening for...
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Advancing Frontiers: Graphene-Based Nano-biosensor Platforms for Cutting-Edge Research and Future Innovations
Graphene and its derivatives have excellent electrical, mechanical, and optical capabilities, making it the perfect foundation for sensing living...
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Strategy for the design of a bioreactor for L-lysine immobilized fermentation using Corynebacterium glutamicum
Biofilm-immobilized fermentation is a novel strategy that has been utilized in L-lysine fermentation. In this study, we describe a strategy for...
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Dynamic control of 4-hydroxyisoleucine biosynthesis by multi-biosensor in Corynebacterium glutamicum
Abstract4-hydroxyisoleucine (4-HIL) has a potential value in treating diabetes. The α-ketoglutarate (α-KG)-dependent isoleucine dioxygenase (IDO) can...
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Rational reformation of Corynebacterium glutamicum for producing L-lysine by one-step fermentation from raw corn starch
AbstractThis article focuses on engineering Corynebacterium glutamicum to produce L-lysine efficiently from starch using combined method of...
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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite...
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Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
BackgroundThe dynamics of phosphatidylserine in the plasma membrane is a tightly regulated feature of eukaryotic cells. Phosphatidylserine (PS) is...
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Biosensor guided effective degradation of anti-nutritional factors via selected soybean fermentation process
Soybean meal (SM) is an important protein source for animal feed, and the β-conglycinin included is a significant allergen that can cause severe...
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Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2
The Arabidopsis H3K9 methyltransferases KRYPTONITE/SUPPRESSOR OF VARIEGATION 3–9 HOMOLOG 4 (KYP/SUVH4), SUVH5 and SUVH6 are redundantly involved in...
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Self-Assembly and Fabrication of Biomaterials onto Transducers and Their Characterization
Biosensor applies the immobilized biomaterials as the sensitive components, and the performances of the biosensor are greatly defined by the activity...
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Exploring l-isoleucine riboswitches for enhancing 4-hydroxyisoleucine production in Corynebacterium glutamicum
ObjectivesTo explore an l -isoleucine (Ile)-induced biosensor for down-regulation of Ile synthesis pathway and enhancement of 4-hydroxyisoleucine...
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Development of peptide-based biosensors for detecting cross-linking and deamidation activities of transglutaminases
Transglutaminases (TGs) are a protein family that catalyzes isopeptide bond formation between glutamine and lysine residues of various proteins....
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Effects of Amino Acids and Overexpression of dapA Gene on the Production of ε-Poly-L-lysine by Streptomyces diastatochromogenes Strains
In this study, the strain Streptomyces diastatochromogenes 6#-7, which efficiently synthesizes ε -Poly-L-lysine, was studied and the effects of 18...
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Increasing l-lysine production in Corynebacterium glutamicum by engineering amino acid transporters
Corynebacterium glutamicum has a long and successful history in the biotechnological production of l -lysine. Besides the adjustment of metabolic...
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AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions
BackgroundmTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET...
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RhoA balances microglial reactivity and survival during neuroinflammation
Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states...
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Metabolic engineering of Corynebacterium glutamicum for the efficient production of β-Alanine from glucose
β-Alanine is the only naturally occurring β-type amino acid, with various applications in the pharmaceutical, food, and chemical industries. Given...
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TRUPATH: An Open-Source Biosensor Platform for Interrogating the GPCR Transducerome
G protein-coupled receptors (GPCRs) are the most highly targeted protein family by United States Food and Drug Administration-approved drugs. Despite...