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Oxidized Low-Density Lipoprotein: Preparation, Validation, and Use in Cell Models
Lipoproteins in plasma are constituted by the least dense chylomicron, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and...
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Apolipoprotein B is associated with CT-angiographic progression beyond low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in patients with coronary artery disease
BackgroundAccumulating evidence indicated that apolipoprotein B (apoB) was the principal lipid determinant of coronary artery disease (CAD)....
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Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis
The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is internalized into cells through LDL receptor (LDLR)-mediated...
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FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis
BackgroundCholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through...
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Macromolecular Interactions of Lipoprotein Lipase (LPL)
Lipoprotein lipase (LPL) is a critical enzyme in humans that provides fuel to peripheral tissues. LPL hydrolyzes triglycerides from the cores of...
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Targeting lectin-like oxidized low-density lipoprotein receptor-1 triggers autophagic program in esophageal cancer
Autophagy is a highly conserved catabolic process to maintain cellular homeostasis. However, dysfunctional autophagy contributes to a...
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Adverse effects of low serum lipoprotein cholesterol on the immune microenvironment in gastric cancer: a case‒control study
BackgroundCholesterol is crucial for tumor immune microenvironment (TIME) remodeling. Serum lipoprotein cholesterol is closely associated with...
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Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study
BackgroundEvidence on the relationship between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and carotid plaques remains limited....
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Effects of portable pedal machines at work on lipoprotein subfraction profile in sedentary workers – the REMOVE study
BackgroundSedentary behaviour at work is a major cause of atherosclerosis, particularly in tertiary workers. However, no studies have ever assessed...
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Effects of superoxide anion attack on the lipoprotein HDL
High-density lipoprotein (HDL) is an anti-atherosclerotic lipoprotein. Thanks to the activity of apolipoprotein ApoA1, the principal protein...
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Lipoprotein(a) in patients with breast cancer after chemotherapy: exploring potential strategies for cardioprotection
Developments in neoadjuvant and adjuvant chemotherapy (CHT) have led to an increase in the number of breast cancer survivors. The determination of an...
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Reductions of copper ion-mediated low-density lipoprotein (LDL) oxidations of trypsin inhibitors, the sweet potato root major proteins, and LDL binding capacities
BackgroundThe root major proteins of sweet potato trypsin inhibitors (SPTIs) or named sporamin, estimated for 60 to 80% water-soluble proteins,...
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The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome
BackgroundNegatively charged very-low-density lipoprotein (VLDL-χ) in metabolic syndrome (MetS) patients exerts cytotoxic effects on endothelial...
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Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke
BackgroundIntima-media thickness (IMT) and small dense low-density lipoprotein cholesterol (sdLDL-C) have been reported to be related to...
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Measures of high-density lipoprotein function in men and women with severe aortic stenosis
BackgroundCalcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis...
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Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets
Reducing circulating lipid levels is the centerpiece of strategies for preventing and treating atherosclerotic cardiovascular disease (ASCVD)....
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Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study
BackgroundCancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after...
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Closing the gaps in patient management of dyslipidemia: step** into cardiovascular precision diagnostics with apolipoprotein profiling
In persons with dyslipidemia, a high residual risk of cardiovascular disease remains despite lipid lowering therapy. Current cardiovascular risk...
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A review on interplay between obesity, lipoprotein profile and nutrigenetics with selected candidate marker genes of type 2 diabetes mellitus
BackgroundType 2 diabetes mellitus, a rapidly growing epidemic, and its frequently related complications demand global attention. The two factors...
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Targeting PCSK9 as a key player in lipid metabolism: exploiting the therapeutic and biosensing potential of aptamers
The degradation of low-density lipoprotein receptor (LDLR) is induced by proprotein convertase subtilisin/kexin type 9 (PCSK9), resulting in elevated...
