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GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator
Cyclic phosphatidic acid (cPA) is a lipid mediator, which regulates adipogenic differentiation and glucose homeostasis by suppressing nuclear...
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LimeMap: a comprehensive map of lipid mediator metabolic pathways
Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made...
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Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice
BackgroundLipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological...
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LiLA: lipid lung-based ATLAS built through a comprehensive workflow designed for an accurate lipid annotation
Accurate lipid annotation is crucial for understanding the role of lipids in health and disease and identifying therapeutic targets. However,...
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Functional multi-organelle units control inflammatory lipid metabolism of macrophages
Eukaryotic cells contain several membrane-separated organelles to compartmentalize distinct metabolic reactions. However, it has remained unclear how...
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Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation
Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2 , leads...
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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis
Lipid droplet (LD) accumulation is a notable feature of obesity-induced cardiomyopathy, while underlying mechanism remains poorly understood. Here we...
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The Interplay of Lipid Signaling in Musculoskeletal Cross Talk: Implications for Health and Disease
The intricate interplay between the muscle and bone tissues is a fundamental aspect of musculoskeletal physiology. Over the past decades, emerging...
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Identification and analysis of lipid metabolism-related genes in allergic rhinitis
BackgroundStudies have shown that the lipid metabolism mediator leukotriene and prostaglandins are associated with the pathogenesis of allergic...
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Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice
BackgroundGut microbiota are involved in the onset and development of chronic intestinal inflammation. The recently described endocannabinoidome...
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Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice
IntroductionRespiratory tract infections are a worldwide health problem for humans and animals. Different cell types produce lipid mediators in...
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Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that affects the whole joint. The pathogenesis of OA is...
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Regulation of fungal raw-starch-degrading enzyme production depends on transcription factor phosphorylation and recruitment of the Mediator complex
Filamentous fungus can produce raw-starch-degrading enzyme (RSDE) that efficiently degrades raw starch below starch gelatinization temperature....
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SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway
Pancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities....
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Futile lipid cycling: from biochemistry to physiology
In the healthy state, the fat stored in our body isn’t just inert. Rather, it is dynamically mobilized to maintain an adequate concentration of fatty...
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Lipid metabolism reprogramming in tumor-associated macrophages and implications for therapy
The tumormicroenvironment (TME) plays a key role in tumor progression. Tumor-associated macrophages (TAMs), which are natural immune cells abundantin...
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Atherogenic Index of Plasma as a Mediator in the association between Body Roundness Index and Depression: insights from NHANES 2005–2018
BackgroundPrevious studies have shown a correlation between depression and obesity, as well as between depression and the Atherogenic Index of Plasma...
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Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway
Iron is an essential micro-element, involved in multiple biological activities in vertebrates. Excess iron accumulation has been identified as an...
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Identification and validation of biomarkers related to lipid metabolism in osteoarthritis based on machine learning algorithms
BackgroundOsteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown.
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TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely...
