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Compensation effect of mortality is a challenge to substantial lifespan extension of humans
Despite frequent claims regarding radical extensions of human lifespan in the near future, many pragmatic scientists caution against excessive and...
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Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals
BackgroundLifespan extension has independently evolved several times during mammalian evolution, leading to the emergence of a group of long-lived...
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Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation
Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues. However, its impact on biological age...
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Calorie restriction mimetic drugs could favorably influence gut microbiota leading to lifespan extension
Calorie restriction (CR) can prolong human lifespan, but enforcing long-term CR is difficult. Thus, a drug that reproduces the effects of CR without...
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Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction
In many organisms, dietary restriction (DR) leads to lifespan extension through the activation of cell protection and pro-longevity gene expression...
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The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the...
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Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction
Dietary restriction (DR) increases lifespan in many organisms, but its underlying mechanisms are not fully understood. Mitochondria play a central...
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Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain...
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Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variation among labs, protocols,...
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Intermittent caloric restriction effectively increases yeast chronological lifespan
BackgroundCaloric restriction (CR) is the most well studied non-genetic factor known to extend the health and lifespan of a wide range of species....
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Lifespan regulation by targeting heme signaling in yeast
Heme is an essential prosthetic group that serves as a co-factor and a signaling molecule. Heme levels decline with age, and its deficiency is...
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Short-term fasting of a single amino acid extends lifespan
Diet and health are strongly linked, though the strict changes in diet required to improve health outcomes are usually difficult to sustain. We...
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Transcriptomic alterations in host parasitoid wasps resulting in extended lifespan due to PpNSRV-1 infection
The parasitoid wasp Pteromalus puparum , a pivotal agent in agricultural ecosystem balance, experiences significant alterations in lifespan due to...
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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system
Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but...
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male...
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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol...
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Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric...
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Glucosylglycerol and proline reverse the effects of glucose on Rhodosporidium toruloides lifespan
Rhodosporidium toruloides is a novel cell factory used to synthesis carotenoids, biosurfactants, and biofuel feedstocks. However, research on R....
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Exogenous glucosylglycerol and proline extend the chronological lifespan of Rhodosporidium toruloides
Glucosylglycerol (GG) is an osmolyte found in a few bacteria (e.g., cyanobacteria) and plants grown in harsh environments. GG protects microbes and...
