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Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variation among labs, protocols,...
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Measuring Replicative Lifespan in Cryptococcus neoformans
Advances in understanding cellular aging research have been possible due to the analysis of the replicative lifespan of yeast cells. Studying...
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DNA methylation rates scale with maximum lifespan across mammals
DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been...
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Calculating Aging: Analysis of Survival Curves in the Norm and Pathology, Fluctuations in Mortality Dynamics, Characteristics of Lifespan Distribution, and Indicators of Lifespan Variation
AbstractThe article describes the history of studies of survival data carried out at the Research Institute of Physico-Chemical Biology under the...
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Lifespan regulation by targeting heme signaling in yeast
Heme is an essential prosthetic group that serves as a co-factor and a signaling molecule. Heme levels decline with age, and its deficiency is...
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male...
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Short-term fasting of a single amino acid extends lifespan
Diet and health are strongly linked, though the strict changes in diet required to improve health outcomes are usually difficult to sustain. We...
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Gut microbial genetic variation modulates host lifespan, sleep, and motor performance
Recent studies have shown that gut microorganisms can modulate host lifespan and activities, including sleep quality and motor performance. However,...
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Compensation effect of mortality is a challenge to substantial lifespan extension of humans
Despite frequent claims regarding radical extensions of human lifespan in the near future, many pragmatic scientists caution against excessive and...
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Effects of Holsteinization on Productive Lifespan of Black-and-White Cows in Smolensk Oblast
AbstractThe aspects of Black-and-White holsteinized cow’s productive lifespan were the objectives of the survey carried out with 9270 Black-and-White...
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Neural correlates of obesity across the lifespan
Associations between brain and obesity are bidirectional: changes in brain structure and function underpin over-eating, while chronic adiposity leads...
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Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals
BackgroundLifespan extension has independently evolved several times during mammalian evolution, leading to the emergence of a group of long-lived...
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Empagliflozin rescues lifespan and liver senescence in naturally aged mice
AbstractEmpagliflozin is currently known to decrease blood glucose levels, delay renal failure, and reduce the risk of cardiovascular death and...
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The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the...
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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol...
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Intermittent caloric restriction effectively increases yeast chronological lifespan
BackgroundCaloric restriction (CR) is the most well studied non-genetic factor known to extend the health and lifespan of a wide range of species....
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Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric...
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Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation
Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues. However, its impact on biological age...
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Transcriptomic alterations in host parasitoid wasps resulting in extended lifespan due to PpNSRV-1 infection
The parasitoid wasp Pteromalus puparum , a pivotal agent in agricultural ecosystem balance, experiences significant alterations in lifespan due to...
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A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan
Autophagy–lysosomal function is crucial for maintaining healthy lifespan and preventing age-related diseases. The transcription factor TFEB plays a...
