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Negative density-dependence buffers against mismatch-induced population decline in the Sinai baton blue butterfly
Phenological mismatches caused by climate change pose a major threat to global biodiversity, yet relatively few studies have reported population...
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Prediction-based approach for quantifying phenological mismatch across landscapes under climate change
ContextClimate change is driving phenological shifts across landscapes, but uncoordinated shifts might cause a potential “phenological mismatch.”...
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Phenological shifts and mismatch with marine productivity vary among Pacific salmon species and populations
Global climate change is shifting the timing of life-cycle events, sometimes resulting in phenological mismatches between predators and prey....
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Strand asymmetry influences mismatch resolution during single-strand annealing
BackgroundBiases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are...
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Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis
Hypermutated neoantigens in cancers with DNA mismatch repair deficiency (dMMR) are prerequisites for favorable clinical responses to...
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Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair
DNA mismatch repair detects and corrects mismatches introduced during DNA replication. The protein MutS scans for mismatches and coordinates the...
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The selection process of licensing a DNA mismatch for repair
DNA mismatch repair detects and removes mismatches from DNA by a conserved mechanism, reducing the error rate of DNA replication by 100- to...
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Mitonuclear mismatch alters nuclear gene expression in naturally introgressed Rhinolophus bats
BackgroundMitochondrial function involves the interplay between mitochondrial and nuclear genomes. Such mitonuclear interactions can be disrupted by...
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The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
BackgroundImprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining...
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Full-Length Single-Cell RNA-Sequencing with FLASH-seq
The single-cell RNA-sequencing (scRNA-seq) field has evolved tremendously since the first paper was published back in 2009 (Tang et al. Nat Methods...
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Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications
Telomere length is a putative biomarker of aging and is associated with multiple age-related diseases. There are limited data on the landscape of...
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Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases...
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Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data
16S ribosomal RNA-based analysis is the established standard for elucidating the composition of microbial communities. While short-read 16S rRNA...
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A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing
Hereditary non-polyposis colorectal cancer, now known as Lynch syndrome (LS) is one of the most common cancer predisposition syndromes and is caused...
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MutL Protein from the Neisseria gonorrhoeae Mismatch Repair System: Interaction with ATP and DNA
AbstractThe mismatch repair system (MMR) ensures the stability of genetic information during DNA replication in almost all organisms. Mismatch repair...
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The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s...
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Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity
We report the first chromosome-length genome assemblies for three species in the mammalian order Pholidota: the white-bellied, Chinese, and Sunda...
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Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimation
Telomeres are regions of repetitive DNA at the ends of linear chromosomes which protect chromosome ends from degradation. Telomere lengths have been...
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Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study
Shorter leukocyte telomere length (LTL) is associated with cardiovascular dysfunction. Whether this association differs between measured and...
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Functional Specifics of the MutL Protein of the DNA Mismatch Repair System in Different Organisms
AbstractA DNA mismatch repair (MMR) system is found in all living organisms. MMR dysfunction at any step of DNA repair leads to an accumulation of...
