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Intratumoural microbiota: from theory to clinical application
Cancer is a major cause of high morbidity and mortality worldwide. Several environmental, genetic and lifestyle factors are associated with the...
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Interactions between diet and gut microbiota in cancer
Dietary patterns and specific dietary components, in concert with the gut microbiota, can jointly shape susceptibility, resistance and therapeutic...
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Utilization of the microbiome in personalized medicine
Inter-individual human variability, driven by various genetic and environmental factors, complicates the ability to develop effective...
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Communication with Gut Microbiota: An Emerging Strategy to Predict and Prevent Cancer
Spectrum of microorganisms that live in and on different parts of the human body is collectively called human microbiome. Human microbiome is...
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The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen...
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The microbial landscape of colorectal cancer
Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire need of improved prevention and treatment strategies. As...
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Long non-coding RNAs in lung cancer: implications for lineage plasticity-mediated TKI resistance
The efficacy of targeted therapy in non-small-cell lung cancer (NSCLC) has been impeded by various mechanisms of resistance. Besides the mutations in...
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Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells
Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling are poorly understood....
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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune signalling adaptor, has a pivotal role in mounting antitumour...
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Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions
Osteosarcoma is a malignant bone tumor that primarily inflicts the youth. It often metastasizes to the lungs after chemotherapy failure, which...
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METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis
BackgroundMETTL3 plays a significant role as a catalytic enzyme in mediating N6-methyladenosine (m 6 A) modification, and its importance in tumour...
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Evolutionary determinants of curability in cancer
The emergence of drug-resistant cells, most of which have a mutated TP53 gene, prevents curative treatment in most advanced and common metastatic...
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Peptide Nanostructured Materials as Drug Delivery Carriers
Peptides are ideal building blocks for biomaterials and nanostructures aimed at advanced drug delivery, with hydrogels playing an elected role for...
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Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic...
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An expanded lexicon for the ubiquitin code
Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and E3 enzymes that modify Lys residues on specific substrates...
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Roles and regulation of tRNA-derived small RNAs in animals
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere...
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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut microbes participate in the progression of tumorigenesis...
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The Intestinal Tumour Microenvironment
The tumour microenvironment (TME) of intestinal tumours is highly complex and comprises a network of stromal cells, tumour cells, immune cells and...
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Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
Fusobacterium nucleatum has long been found to cause opportunistic infections and has recently been implicated in colorectal cancer; however, it is a...
