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Optogenetic Activation of Intracellular Nanobodies
Intracellular antibody fragments such as nanobodies and scFvs are powerful tools for imaging and for modulating and neutralizing endogenous target...
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Single-Domain Antibodies for Intracellular Toxin Neutralization
Ricin is a plant-derived toxin with a history as a biothreat agent. The toxin’s enzymatic subunit, ricin toxin A chain (RTA), is a...
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Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers
Alterations of adult neurogenesis have been reported in several Alzheimer's disease (AD) animal models and human brains, while defects in this...
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Genetically encoded barcodes for correlative volume electron microscopy
While genetically encoded reporters are common for fluorescence microscopy, equivalent multiplexable gene reporters for electron microscopy (EM) are...
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Application of Antibody Fragments in ADCs
Traditional ADC drugs have a large molecular form and a long half-life, resulting in poor tissue penetration and prone to off-target toxicity....
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Building sophisticated sensors of extracellular cues that enable mammalian cells to work as “doctors” in the body
Mammalian cells are inherently capable of sensing extracellular environmental signals and activating complex biological functions on demand. Advances...
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Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy
Tissue morphogenesis results from a tight interplay between gene expression, biochemical signaling and mechanics. Although sequencing methods allow...
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On the cutting edge: protease-based methods for sensing and controlling cell biology
Sequence-specific proteases have proven to be versatile building blocks for tools that report or control cellular function. Reporting methods link...
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Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins
Intracellular antibodies have become powerful tools for imaging, modulating and neutralizing endogenous target proteins. Here, we describe an...
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Biological roles of the B cell receptor-associated protein 31: Functional Implication in Cancer
BAP31 is a ubiquitously expressed integral membrane protein of the endoplasmic reticulum. BAP31 is involved in various biological and molecular...
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Unlocking the promise of mRNA therapeutics
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering...
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Regenerative Potential of Platelet Rich Fibrin (PRF) in Socket Preservation in Comparison with Conventional Treatment Modalities: A Systematic Review and Meta-Analysis
BackgroundPlatelet rich fibrin (PRF) has shown great potential in osteogenesis; however, some studies still question utilizing it as a grafting...
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Brain histone beta-hydroxybutyrylation couples metabolism with gene expression
Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be a...
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Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells
Here, we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation. By excising the natural...
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Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs
Despite their fundamental role in assessing (patho)physiological cell states, conventional gene reporters can follow gene expression but leave scars...
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Anwendungsgebiete für rekombinante Antikörper
Antikörper werden seit Jahrzenten in zahlreichen unterschiedlichen Assays eingesetzt. Der wohl meistverbreitete Assay in der Forschung und Diagnostik...
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Prospective Applications of Single-Domain Antibodies in Biomedicine
AbstractMethods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and...
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Selenium in Food Chain in Relation to Human and Animal Nutrition and Health
Selenium (Se) is a crucial element with high metabolic activity for human health. The primary source of Se for animals and humans is diet. Dietary...
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Microbial Nanobionic Engineering: Translational and Transgressive Science of an Antidisciplinary Approximation
Combining in a single space microbiology, nanotechnology, synthetic biology, and biosensors requires a different approach to those used so far. First...