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Ribosomal proteins: the missing piece in the inflammation puzzle?
Ribosomal proteins (RPs) are constituents of macromolecular machinery, ribosome that translates genetic information into proteins. Besides ribosomal...
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Regulation of translation by site-specific ribosomal RNA methylation
Ribosomes are complex ribozymes that interpret genetic information by translating messenger RNA (mRNA) into proteins. Natural variation in ribosome...
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Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome. Since then, organisms have dedicated great efforts to optimize...
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The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A
Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the 5′ end of mRNA by the cap-binding complex eIF4F,...
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Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-resolution ribosome...
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Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs
Selective translation allows to orchestrate the expression of specific proteins in response to different signals through the concerted action of...
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Probing the RNA Structure-Dependent RNA Regulations and Functions
RNAs form complex structures in vivo to perform diverse functions. These RNA structures dynamically change in response to internal cellular...
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Cell entry and release of quasi-enveloped human hepatitis viruses
Infectious hepatitis type A and type E are caused by phylogenetically distinct single-stranded, positive-sense RNA viruses that were once considered...
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Structure of the ISW1a complex bound to the dinucleosome
Nucleosomes are basic repeating units of chromatin and form regularly spaced arrays in cells. Chromatin remodelers alter the positions of nucleosomes...
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Comparative genome-wide analysis of circular RNAs in Brassica napus L.: target-site versus non-target-site resistance to herbicide stress
Circular RNAs (circRNAs), a class of non-coding RNA molecules, are recognized for their unique functions; however, their responses to herbicide...
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Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation
Glucosylceramide is the primary molecule of glycosphingolipids, and its metabolic regulation is crucial for life. Defects in the catabolizing enzyme,...
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Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation
BackgroundThe DNA sequences encoding ribosomal RNA genes (rRNAs) are commonly used as markers to identify species, including in metagenomics samples...
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CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs
BackgroundSome circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner....
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Characterization of a putative ribosome binding site at the 5′ untranslated region of bovine heat shock protein 90
Untranslated regions (UTRs) of the transcripts play significant roles in translation regulation and continue to raise many intriguing questions in...
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An outlook on potential protein targets of COVID-19 as a druggable site
BackgroundSARS-CoV-2 which causes COVID-19 disease has started a pandemic episode all over the world infecting millions of people and has created...
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Detection of RNA Structure and Interactions Using Nanopore Technology
RNA molecules are highly versatile and dynamic components within cells that orchestrate fundamental molecular biological processes, including...
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Structure and Functions of RNA G-quadruplexes
G-quadruplexes (G4s) are four-stranded nucleic acid secondary structures that are formed by the stacking of square planar guanine arrangements and...
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Dynamics of Eukaryotic mRNA Structure during Translation
AbstractCurrently, there is no single concept of the optimal spatial structure of mRNA during translation. It is known that many proteins, associated...
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RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma
Metabolic reprogramming is a major feature of cancer, and aerobic glycolysis is one of the most widely studied metabolic reprogramming processes....
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Structure and function of the N-terminal extension of the formin INF2
In INF2—a formin linked to inherited renal and neurological disease in humans—the DID is preceded by a short N-terminal extension of unknown...
