Search
Search Results
-
The effect of data transformation on low-dimensional integration of single-cell RNA-seq
BackgroundRecent developments in single-cell RNA sequencing have opened up a multitude of possibilities to study tissues at the level of cellular...
-
Statistical Methods for Integrative Clustering of Multi-omics Data
Cancers are heterogeneous diseases caused by accumulated mutations or abnormal alterations at multi-levels of biological processes including...
-
Immature rat testis sustained long-term development using an integrative model
BackgroundXenotransplantation has been primarily performed using fresh donor tissue to study testicular development for about 20 years, and whether...
-
Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma
The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains...
-
Potent IPTG-inducible integrative expression vectors for production of recombinant proteins in Bacillus subtilis
The IPTG-inducible promoter family, P grac , allows high protein expression levels in an inducible manner. In this study, we constructed IPTG-inducible...
-
Integrative transcriptome analysis uncovers common components containing CPS2 regulated by maize lncRNA GARR2 in gibberellin response
Main conclusionThe combined transcriptome outcome provides an important clue to the regulatory cascade centering on lncRNA GARR2 and CPS2 gene in GA...
-
The global integrative network: integration of signaling and metabolic pathways
The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes. The...
-
Random transposon mutagenesis identifies genes essential for transformation in Methanococcus maripaludis
Natural transformation, the process whereby a cell acquires DNA directly from the environment, is an important driver of evolution in microbial...
-
Plant taxonomic species and their role in the workflow of integrative species delimitation
The species of classical taxonomy are examined with a view to their future role in integrative taxonomy. Taxonomic species are presented as the...
-
Biolistic Transformation of Cryptococcus neoformans
Biolistic transformation of Cryptococcus neoformans is used as a molecular tool to genetically alter or delete targeted genes. The DNA is introduced...
-
Genetic and Functional Characterization of a Salicylate 1-monooxygenase Located on an Integrative and Conjugative Element (ICE) in Pseudomonas stutzeri AJR13
Pseudomonas stutzeri strain AJR13 was isolated for growth on the related compounds biphenyl (BPH) and diphenylmethane (DPM). The BPH and DPM...
-
Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders
Anxiety disorders are the most prevalent mental disorders. However, the genetic etiology of anxiety disorders remains largely unknown. Here we...
-
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Map** single-cell sequencing profiles to comprehensive reference datasets provides a powerful alternative to unsupervised analysis. However, most...
-
Integrative network-based approaches identified systems-level molecular signatures associated with gallbladder cancer pathogenesis from gallstone diseases
Gallbladder cancer (GBC) is one of the most fatal malignancies of the biliary tract system and is ranked sixth among the neoplasms of the...
-
Spider’s Silk as a Potential Source of Antibiotics: An Integrative Review
Spiders produce webs, which are still a largely unexplored source of antibacterial compounds, although the reports of its application in the medical...
-
Catch me if you can: capturing microbial community transformation by extracellular DNA using Hi-C sequencing
The transformation of environmental microorganisms by extracellular DNA is an overlooked mechanism of horizontal gene transfer and evolution. It...
-
The gut microbiome-metabolome dataset collection: a curated resource for integrative meta-analysis
Integrative analysis of microbiome and metabolome data obtained from human fecal samples is a promising avenue for better understanding the interplay...
-
An Integrative Ecological Drought Framework to Span Plant Stress to Ecosystem Transformation
Droughts have increased globally in the twenty-first century and are expected to become more extreme and widespread in the future. Assessments of how...
-
Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model
BackgroundMicroRNAs (miRNAs) are important post-transcriptional gene regulators controlling cellular lineage specification and differentiation during...
