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Size-dependent and -independent prey selection of dinoflagellates
Mechanisticapproachestoplanktonfood-websoftenrelyonsize-basedmodels.Thesemodelsdescribe predator–preyrelationshipsbasedonpredator body or cell size....
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Protecting commonplace biodiversity under international conservation law
A contemporary appraisal of the extent to which international conservation law provides for the protection of commonplace biodiversity. It is argued...
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A Law of Redundancy Compounds the Problem of Cancer and Precision Medicine
Genetics and molecular biology research have progressed for over a century; however, no laws of biology resembling those of physics have been...
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Selection index theory for populations under directional and stabilizing selection
BackgroundThe purpose of a selection index is that its use to select animals for breeding maximizes the profit of a breed in future generations. The...
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Environment-specificity and universality of the microbial growth law
As the nutrient quality changes, the fractions of ribosomal proteins in the proteome are usually positively correlated with the growth rates due to...
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Natural Selection
Before turning to the simulation of variants linked to targets of natural selection, we focus here on the evolution of the targeted locus itself....
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Using pseudo-absence models to test for environmental selection in marine movement ecology: the importance of sample size and selection strength
BackgroundUnderstanding the selection of environmental conditions by animals requires knowledge of where they are, but also of where they could have...
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Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response
Cancer is an evolutionary process shaped by selective pressure from the microenvironments. However, recent studies reveal that certain tumors undergo...
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Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection
Two long-standing challenges in theoretical population genetics and evolution are predicting the distribution of phenotype diversity generated by...
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Measuring frequency-dependent selection in culture
The frequency of a cultural trait can influence its tendency to be copied. We develop a maximum-likelihood method to measure such frequency-dependent...
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Phenomic Selection: A New and Efficient Alternative to Genomic Selection
Recently, it has been proposed to switch molecular markers to near-infrared (NIR) spectra for inferring relationships between individuals and further...
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Comparison of cancer subtype identification methods combined with feature selection methods in omics data analysis
BackgroundCancer subtype identification is important for the early diagnosis of cancer and the provision of adequate treatment. Prior to identifying...
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A Microbe’s Environment and Natural Selection
If the Julian Adams experiment would have been conducted in a different environment, for example as a batch transfer experiment or involving...
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Get out from my field! The role of agricultural crops in sha** the habitat selection by and suitability for the crested porcupine in Central Italy
‘Agricultural pests’ is a locution used to indicate those wild species considered as dangerous to crops. The crested porcupine Hystrix cristata is a...
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Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
BackgroundDespite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long...
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Phenomic selection in wheat breeding: identification and optimisation of factors influencing prediction accuracy and comparison to genomic selection
Key messagePhenomic selection is a promising alternative or complement to genomic selection in wheat breeding. Models combining spectra from...
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Institutional Dynamics Under Selection Pressure and Uncertainty
Simplified probability models of institutional function under selection pressure and stochastic burden that are based on the asymptotic limit...
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Genetic legacy and adaptive signatures: investigating the history, diversity, and selection signatures in Rendena cattle resilient to eighteenth century rinderpest epidemics
BackgroundRendena is a dual-purpose cattle breed, which is primarily found in the Italian Alps and the eastern areas of the Po valley, and recognized...
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Topology-enhanced molecular graph representation for anti-breast cancer drug selection
BackgroundBreast cancer is currently one of the cancers with a higher mortality rate in the world. The biological research on anti-breast cancer...
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BPM1 regulates RdDM-mediated DNA methylation via a cullin 3 independent mechanism
Key messageBPM1 interacts with components of the DDR complex and stimulates DNA methylation at CHH sites, suggesting its involvement in the RdDM...
