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The implications of FASN in immune cell biology and related diseases
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular physiological process in which nutrients are used for energy...
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A costimulatory molecule-related signature in regard to evaluation of prognosis and immune features for clear cell renal cell carcinoma
Costimulatory molecules have been proven to enhance antitumor immune responses, but their roles in clear cell renal cell carcinoma (ccRCC) remain...
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A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients
BackgroundEndometrial cancer (EC) is the most common gynecologic malignancy in developed countries and its prevalence is increasing. As an emerging...
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The landscape of immune checkpoint-related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responses
Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) by cooperating with immunity genes in tumor immunization....
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Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone in the United States (US), 66,200 new cases and 13,030 deaths...
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Immune-related biomarkers predict the prognosis and immune response of breast cancer based on bioinformatic analysis and machine learning
Breast cancer (BC) is the malignancy with the highest mortality rate among women, identification of immune-related biomarkers facilitates precise...
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Potential prognostic value of a eight ferroptosis-related lncRNAs model and the correlative immune activity in oral squamous cell carcinoma
BackgroundTo investigate the prognostic value of ferroptosis-related long noncoding RNAs (lncRNAs) in oral squamous cell carcinoma (OSCC) and to...
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Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response
Neoadjuvant immune-checkpoint blockade therapy only benefits a limited fraction of patients with glioblastoma multiforme (GBM). Thus, targeting other...
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The fungal quorum-sensing molecule, farnesol, regulates the immune response of vaginal epithelial cells against Candida albicans
BackgroundFarnesol is a Candida -secreted quorum-sensing molecule of great interest as a potential antifungal agent for serious and hardly curable...
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Plant-derived bioactive compounds as key players in the modulation of immune-related conditions
The immune system is a complex and fundamental network for organism protection. A minimal unbalance in the host defense system homeostasis can...
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High-throughput virtual screening of small-molecule inhibitors targeting immune cell checkpoints to discover new immunotherapeutics for human diseases
Immunotherapy is widely used to treat various cancers, and the drugs used are called immune checkpoint (ICP) inhibitors. Overexpression of immune...
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Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis
BackgroundSepsis is a high mortality disease which seriously threatens human life and health, for which the pathogenetic mechanism still unclear....
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Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma
ObjectiveThe aim of this study is to investigate the effect of let-7c-5p on the malignant behaviors of hepatocellular carcinoma (HCC) and its...
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Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases
The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark of the aging process and many age-related diseases. This...
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Novel six-gene prognostic signature based on colon adenocarcinoma immune-related genes
BackgroundColon adenocarcinoma (COAD) is one of the most common gastrointestinal tumors worldwide, and immunotherapy is one of the most promising...
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A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer
BackgroundIdentifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we...
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Screening of primary open-angle glaucoma diagnostic markers based on immune-related genes and immune infiltration
PurposePrimary open-angle glaucoma (POAG) continues to be a poorly understood disease. Although there were multiple researches on the identification...
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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury
Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and...
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A novel mitochondria-related gene signature in esophageal carcinoma: prognostic, immune, and therapeutic features
Esophageal carcinoma (ESCA) is a common and lethal malignant tumor worldwide. The mitochondrial biomarkers were useful in finding significant...
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Single-cell RNA sequencing integrated with bulk RNA sequencing analysis identifies a tumor immune microenvironment-related lncRNA signature in lung adenocarcinoma
BackgroundRecently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME). Nevertheless,...
