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IL-25 blockade augments antiviral immunity during respiratory virus infection
IL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated....
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Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1
ObjectiveTo compare the effects of human Trypsin-1 signal peptide and pro-peptide on the expression and secretion efficiency of human Interleukin-25...
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Long non-coding RNA FOXD3-AS1 regulates the expression and secretion of IL-25 in nasal epithelial cells to inhibit Th2 type immunoreaction in allergic rhinitis
Long non-coding RNA FOXD3-AS1 is associated with allergic rhinitis (AR). This article aims to demystify the role of FOXD3-AS1 in AR. We compared...
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Microwave-assisted extraction of lipid and eicosapentaenoic acid from the microalga Nanochloropsis sp. using imidazolium-based ionic liquids as an additive in water
This study employed 1-ethyl-3-methyl imidazolium chloride ([EMIM][Cl]) as an additive in an aqueous medium, combined with microwave-assisted...
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Thymoquinone improves experimental autoimmune encephalomyelitis by regulating both pro-inflammatory and anti-inflammatory cytokines
Introduction Multiple sclerosis (MS) is an autoimmune condition marked by inflammation and the loss of myelin in the central nervous system (CNS)....
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Curcumin’s spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses
BackgroundMultiple sclerosis (MS) is an autoimmune central nervous system (CNS) disorder indicated by demyelination, chronic inflammation, and...
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Th17-Related Cytokines Involved in Fluoride-Induced Cecal and Rectal Barrier Damage of Ovariectomized Rats
To investigate fluoride (F)-induced intestine barrier damage and the role of estrogen deficiency in this progress, a rat model of estrogen deficiency...
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Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13
Group 2 innate lymphoid cells (ILC2s) play important tissue resident roles in anti-parasite immunity, allergic immune response, tissue homeostasis,...
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The effect of hesperetin on estrogen receptor gene expression and its relationship with the downstream pathways of estrogen receptor alpha
BackgroundEstrogen receptor (ER) is a transcription factor that affects the expression of some genes involved in the progression and development of...
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Comparison of the partial root drying and conventional drip irrigation regimes on seed, oil yield quality, and economic return for peanut crop
This study compares conventional drip irrigation (CDI) and partial root drying (PRD) on yield components, oil quality, and economic return of peanut...
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Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer’s disease mice model
BackgroundMillions of people around the globe are affected by Alzheimer’s disease (AD). This crippling condition has no treatment despite intensive...
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Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation
BackgroundCadmium (Cd) is a strong toxic agent and causes serious damage to testicular tissues. Chrysin (CHR) is a natural flavonoid with many...
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Arsenic Induces Blood‒Brain Barrier Disruption and Regulates T Lymphocyte Subpopulation Differentiation in the Cerebral Cortex and Hippocampus Associated with the Nrf2 Pathway In Vivo
Increasing evidence has confirmed that the nervous system shows innate and adaptive immunity, which also participates in nerve damage. This study...
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Copper Promotes LPS-Induced Inflammation via the NF-кB Pathway in Bovine Macrophages
Inflammation is a complex physiological process that enables the clearance of pathogens and repairing damaged tissues. Elevated serum copper...
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Assessment of reproductive stage drought tolerance using stress indices in improved restorer lines of KMR-3R in rice
Drought stress during the reproductive stage is an evident limitation of rice grain yield. The present study aimed to assess the reproductive stage...
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Thioredoxin-1 inhibits amyloid-β25–35-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells
BackgroundAlzheimer’s disease (AD), the most common neurodegenerative disease, is charactered by these accepted pathological features, such as...
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Temperature fluctuation alters immuno-antioxidant response and enhances the susceptibility of Oreochromis niloticus to Aeromonas hydrophila challenge
In Egypt, the temperature of the water fluctuates drastically, reaching a daytime high of 25 °C and a nighttime low of 15 °C, respectively, in the...
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Role of apoptosis and autophagy in mediating tramadol-induced neurodegeneration in the rat hippocampus
BackgroundTramadol (TRA) is an analgesic prescribed for treating mild to moderate pains, the abuse of which has increased in recent years. Chronic...
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Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats
Polycystic ovarian syndrome (PCOS) is considered the most frequent gynecological endocrine disorder that causes anovulatory infertility. The current...
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Impact of Combined Aerobic Training and Magnesium Supplementation on Serum Biomarkers and microRNA-155 and microRNA-21 Expression in Adipose Tissue of Type 2 Diabetic Rats: An Eight-Week Interventional Study
BackgroundType 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by insulin resistance and chronic inflammation. Aerobic...
