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Identification and functional characterization of fish IL-17 receptors suggest important roles in the response to nodavirus infection
Th17 is a lymphocyte T helper (Th) subpopulation relevant in the control and regulation of the immune response characterized by the production of...
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IL-17 Signaling in the Tumor Microenvironment
Inflammation is recognized as representing a double-edged sword in terms of tumor growth, in some instances contributing to attenuation of growth and...
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Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
BackgroundPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats...
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Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment
Eczema is a common chronic dermatological disease. Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term...
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IL-17 in wound repair: bridging acute and chronic responses
Chronic wounds, resulting from persistent inflammation, can trigger a cascade of detrimental effects including exacerbating inflammatory cytokines,...
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Tissue Engineered Mini-Cornea Model for Eye Irritation Test
Background :Eye irritation tests with animals have been conducted for a long time. However, the subjective decision to irritation, the...
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Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments
Inflammatory bowel disease (IBD) is associated with gut dysbiosis and can lead to colitis-associated malignancies. Bacteroides uniformis (Bu)...
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Interleukin-17 as a key player in neuroimmunometabolism
In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression...
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Review of natural plant-derived seco-triterpenoids and derived saponins from 2020 to 2023: new compounds, distributions, diverse activities and structure–activity relationships
Seco- triterpenoids are a unique class of triterpenoids possessing distinct structural features. Based on the differences in their parent nucleus,...
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Interface between Resolvins and Efferocytosis in Health and Disease
Acute inflammation resolution acts as a vital process for active host response, tissue support, and homeostasis maintenance, during which resolvin D...
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Insights into the impact of hepatitis B virus on hepatic stellate cell activation
During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The...
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Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson’s disease
Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN); the...
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Mechanism of iron on the intestinal epithelium development in suckling piglets
This study aimed to investigate the mechanism of iron on intestinal epithelium development of suckling piglets. Compared with newborn piglets,...
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A comprehensive network map of IL-17A signaling pathway
Interleukin-17A (IL-17A) is one of the member of IL-17 family consisting of other five members (IL-17B to IL-17F). The Gamma delta (γδ) T cells and T...
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IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism
Osteoclasts consume an amount of adenosine triphosphate (ATP) to perform their bone resorption function in the development of osteoporosis. However,...
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USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction
TNF receptor-associated factor 6 (TRAF6)-BECN1 signaling axis plays a pivotal role in autophagy induction through ubiquitination of BECN1, thereby...
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Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway
Background and PurposeHyperoxia-induced acute lung injury (HALI) is a critical life-threatening disorder characterized by severe infiltration immune...
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Reversal of gentamicin sulfate resistance in avian pathogenic Escherichia coli by matrine combined with berberine hydrochloride
In recent years, the evolution of antibiotic resistance has led to the inefficacy of several antibiotics, and the reverse of resistance was a novel...
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Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer
A common stage of advanced prostate cancer is castration-resistant prostate cancer (CRPC), greater understanding of which is required in order to...
