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Novel and known minor alleles of CNTNAP2 gene variants are associated with comorbidity of intellectual disability and epilepsy phenotypes: a case–control association study reveals potential biomarkers
BackgroundNeurodevelopmental disorders are heterogeneous due to underlying multiple shared genetic pathways and risk factors. Intellectual...
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CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
In essence, the β 2 adrenergic receptor (β 2 AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate...
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Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty
Methylmalonic acid (MMA), a by-product of propionate metabolism, is known to increase with age. This study investigates the potential of serum MMA...
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Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacology
The novel coronavirus disease (COVID-19), which emerged in Wuhan, China, is continuously spreading worldwide, creating a huge burden on public health...
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Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be...
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Gut microbiota regulation of inflammatory cytokines and microRNAs in diabetes-associated cognitive dysfunction
AbstractType 2 diabetes mellitus (T2DM) has a major comorbidity known as diabetes-associated cognitive dysfunction (DACD). Studies have demonstrated...
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Neurological diagnostic tests for patients with and without delirium: a prospective observational study
Since most of the precipitating factors of delirium are not due to neurological disorders, neurological diagnostic tests (NDTs) may be of limited...
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Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
BackgroundLipid management in clinic is critical to the prevention and treatment of Chronic kidney disease (CKD), while the manifestations of lipid...
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Mendelian randomization reveals causal effects of kidney function on various biochemical parameters
The kidney is a vital organ with diverse biological effects and the burden of kidney function impairment is increasing in modern medicine. As the...
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Independent and joint associations of monocyte to high-density lipoprotein-cholesterol ratio and body mass index with cardiorenal syndrome: insights from NHANES 2003–2020
BackgroundWith the development of pathophysiology, cardiorenal syndrome (CRS), a complex and severe disease, has received increasing attention....
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A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for viral infection. We use high-throughput yeast...
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Associations between the TyG index and the ɑ-Klotho protein in middle-aged and older population relevant to diabetes mellitus in NHANES 2007–2016
BackgroundThe anti-aging protein Klotho has diverse functions in antioxidative stress and energy metabolism through several pathways. While it has...
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Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function
Despite recent efforts to increase diversity in genome-wide association studies (GWASs), most loci currently associated with kidney function are...
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Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity
MultiMorbidity (MM), defined as the co-occurrence of two or more chronic conditions, is associated with poorer health outcomes, such as recurrent...
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Cardiometabolic and renal phenotypes and transitions in the United States population
Cardiovascular and renal conditions have both shared and distinct determinants. In this study, we applied unsupervised clustering to multiple rounds...
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Development and validation of a new nomogram to screen for MAFLD
Background and aimMetabolic dysfunction-associated fatty liver disease (MAFLD) poses significant health and economic burdens on all nations. Thus,...
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Maximizing the value of twin studies in health and behaviour
In the classical twin design, researchers compare trait resemblance in cohorts of identical and non-identical twins to understand how genetic and...
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The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease
BackgroundAutologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might...
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Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment
Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a disease of older adults (the median age at diagnosis is...
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Incidence of Invasive Infections Among Hemato-Oncology Patients with Significant Burden of Candida in Stool
Candidemia is a serious infection associated with increased mortality. It is unclear whether a high concentration of Candida in stool in patients...