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Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be...
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A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats
Patients with liver cirrhosis may develop covert or minimal hepatic encephalopathy (MHE). Hyperammonemia (HA) and peripheral inflammation play...
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Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
BackgroundPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats...
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Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats
Patients with liver cirrhosis show hyperammonemia and peripheral inflammation and may show hepatic encephalopathy with cognitive impairment,...
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Astrocytic NMDA Receptors
AbstractAstrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition....
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Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study
Previous studies have shown that human liver stem-like cells (HLSCs) may undergo differentiation in vitro into urea producing hepatocytes and in vivo...
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Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology
BackgroundPropionic acidemia is an inborn error of metabolism caused by a deficiency in the mitochondrial enzyme propionyl-CoA carboxylase that...
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Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia
Schizophrenia is a severe psychotic disorder characterized by positive and negative symptoms, but their neural bases remain poorly understood. Here,...
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Fluxomics reveals cellular and molecular basis of increased renal ammoniagenesis
The kidney plays a critical role in excreting ammonia during metabolic acidosis and liver failure. The mechanisms behind this process have been...
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Identification of a novel homozygous intron 3 splice site (A>T) mutation in the ARG1 gene in cerebral palsy pediatric cases from Odisha, India
BackgroundArginase enzyme is essential for the catalysis of the last step of the urea cycle, resulting in the conversion of l -arginine to l -ornithine...
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The possible role of Helicobacter pylori in liver diseases
According to previous studies, Helicobacter pylori infection is associated with liver disease. In order to better understand the risk of acquiring...
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Role of ammonia for brain abnormal protein glycosylation during the development of hepatitis B virus-related liver diseases
BackgroundAmmonia is the most typical neurotoxin in hepatic encephalopathy (HE), but the underlying pathophysiology between ammonia and aberrant...
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Impaired Enzymatic Antioxidant Defense in Erythrocytes of Rats with Ammonia-Induced Encephalopathy: Role of NMDA Receptors
AbstractHepatic encephalopathy (HE), a neuropsychiatric disorder develo** in patients with severe hepatic dysfunction, has been known for more than...
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Activation of the Cannabinoid Receptors Suppresses Hyperexcitation of Rat Hippocampal Neuronal Networks In Vitro
Abstract—Cannabinoid receptors (CBRs) play a key role in various physiological processes, including neurogenesis, synaptic plasticity, immune...
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Secondary Dysfunction of the Intestinal Barrier in the Pathogenesis of Complications of Acute Poisoning
AbstractThe last decade has been marked by an exponential increase in the number of publications on the physiological role of the normal human gut...
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A review of dietary approaches for ammonia toxicity remediation in fish
We reviewed available data regarding the benefits of feed additives for mitigation of ammonia toxicity in fish. We first emphasized the toxic effects...
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Gut Barrier in Critical States of the Body
AbstractThe intestinal barrier (IB) is a system of diffusion barriers separating the intestinal chyme and blood. The aim of the review is to identify...
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mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-1273 and BNT162b2 displayed...
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Identification and characterization of the largest deletion in the PCCA gene causing severe acute early-onset form of propionic acidemia
Whole-exome sequencing (WES) is an excellent method for the diagnosis of diseases of uncertain or heterogeneous genetic origin. However, it has...
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Anti-cancer effect of in vivo inhibition of nitric oxide synthase in a rat model of breast cancer
Increased expression of nitric oxide synthase (NOS) is associated with different cancers such as cervical, breast, lung, brain, and spinal cord....
