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Brain age prediction across the human lifespan using multimodal MRI data
Measuring differences between an individual’s age and biological age with biological information from the brain have the potential to provide...
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Age-related changes in human brain functional connectivity using graph theory and machine learning techniques in resting-state fMRI data
Aging is the basis of neurodegeneration and dementia that affects each endemic in the body. Normal aging in the brain is associated with progressive...
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Characteristics of the Involvement of Hidden Nodes in the Activity of Human Brain Systems Revealed on fMRI Data
Abstract —Currently, it is generally accepted that brain functions are based on the systemic principle. At the same time, knowledge about the...
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Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases
The intricate relationship between the central nervous system (CNS) and the immune system plays a crucial role in the pathogenesis of various...
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The evolution of human altriciality and brain development in comparative context
Human newborns are considered altricial compared with other primates because they are relatively underdeveloped at birth. However, in a broader...
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Profiling human brain vascular cells using single-cell transcriptomics and organoids
Angiogenesis and neurogenesis are functionally interconnected during brain development. However, the study of the vasculature has trailed other brain...
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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations....
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Fermentation technology as a driver of human brain expansion
Brain tissue is metabolically expensive. Consequently, the evolution of humans’ large brains must have occurred via concomitant shifts in energy...
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BrainTACO: an explorable multi-scale multi-modal brain transcriptomic and connectivity data resource
Exploring the relationships between genes and brain circuitry can be accelerated by joint analysis of heterogeneous datasets from 3D imaging data,...
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The brain time toolbox, a software library to retune electrophysiology data to brain dynamics
Human thought is highly flexible, achieved by evolving patterns of brain activity across groups of cells. Neuroscience aims to understand cognition...
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High-contrast en bloc staining of mouse whole-brain and human brain samples for EM-based connectomics
Connectomes of human cortical gray matter require high-contrast homogeneously stained samples sized at least 2 mm on a side, and a mouse whole-brain...
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Expression profiles of the autism-related SHANK proteins in the human brain
BackgroundSHANKs are major scaffolding proteins at postsynaptic densities (PSDs) in the central nervous system. Mutations in all three family members...
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Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM
BackgroundQuantifying cell-type abundance in bulk tissue RNA-sequencing enables researchers to better understand complex systems. Newer deconvolution...
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Human brain responses are modulated when exposed to optimized natural images or synthetically generated images
Understanding how human brains interpret and process information is important. Here, we investigated the selectivity and inter-individual differences...
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A mesocorticolimbic signature of pleasure in the human brain
Pleasure is a fundamental driver of human behaviour, yet its neural basis remains largely unknown. Rodent studies highlight opioidergic neural...
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Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia
Schizophrenia may represent a trade-off in the evolution of human-specific ontogenetic mechanisms that guide neurodevelopment. Human Accelerated...
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Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system
Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed...
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Replicable brain–phenotype associations require large-scale neuroimaging data
Numerous neuroimaging studies have investigated the neural basis of interindividual differences but the replicability of brain–phenotype associations...
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Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain
Competition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in...
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Multifaceted atlases of the human brain in its infancy
Brain atlases are spatial references for integrating, processing, and analyzing brain features gathered from different individuals, sources, and...
