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Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
BackgroundInterferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells...
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Mechanisms of UV-induced human lymphocyte apoptosis
The article reviews the results of the studies of marker parameters (indicators) of various pathways and mechanisms of apoptosis of lymphocytes in...
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A biphenotypic lymphocyte subset displays both T- and B-cell functionalities
T cell/B cell mixed phenotypic lymphocytes have been observed in different disease contexts, yet their presence and function in physiological...
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Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Immunosenescence is the age-related changes in the immune system, namely, progressively higher levels of circulating inflammatory markers,...
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Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45 Protein Stability Regulator
AbstractLymphocyte phosphatase-associated phosphoprotein (LPAP) is a binding partner of the phosphatase CD45, but its function remains poorly...
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Mini-αA-Crystallin Stifled Melittin-Induced Haemolysis and Lymphocyte Lysis
Melittin, the most potent pharmacological ingredient of honey bee venom, induces haemolysis, lymphocyte lysis, long-term pain, localised...
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Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable...
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Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity
Cancer cells can evade immune elimination by activating immunosuppressive signaling pathways in the tumor microenvironment (TME). Targeting...
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Method for Identifying Galectin Ligands on Lymphocyte Membrane Glycoproteins
Glycosylation is one of the most common protein posttranslational modifications. Most human lymphocyte membrane receptors are modified by diverse...
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Combined Detection of IFN-γ and Lymphocyte Subsets with Activation Indicators in the Clinical Application of Mycobacterium Tuberculosis Infection at Different Times
The immune status of mycobacterium tuberculosis ( MTB ) infection is essential for the diagnosis and treatment of this disease. In this work, we aim to...
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Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing
Atlantic Cod ( Gadus morhua ) has lost the major histocompatibility complex class II presentation pathway. We recently identified CD8-positive T cells,...
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T Lymphocyte Metabolic Features and Techniques to Modulate Them
AbstractT cells demonstrate high degree of complexity and broad range of functions, which distinguish them from other immune cells. Throughout their...
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The broad impact of cell death genes on the human disease phenome
Cell death mediated by genetically defined signaling pathways influences the health and dynamics of all tissues, however the tissue specificity of...
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Platelet-lymphocyte co-culture serves as an ex vivo platform of dynamic heterotypic cross-talk
Platelets are well known for their roles in hemostasis and thrombosis, and are increasingly recognized for their abilities to interact with white...
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Neutrophil-to-lymphocyte ratio and red blood cell distribution width to platelet ratio and their relationships with inflammatory and antioxidant status in dogs with different stages of heart failure due to myxomatous mitral valve disease
We aimed to evaluate the red blood cell distribution width-to-platelet ratio (RDW/PLT) with other complete blood cell count (CBC) indices and their...
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Cytogenetic Analysis of the Peripheral Blood Lymphocyte Cultures of a Patient Some Time after Accidental Irradiation Using the Three-Color FISH Method
Abstract —The results of cytogenetic analysis using mainly three-color FISH staining of peripheral blood lymphocyte chromosomes in a single patient...
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Donor-derived CAR-T therapy improves the survival of relapsed B-ALL after allogeneic transplantation compared with donor lymphocyte infusion
Chimeric antigen receptor (CAR)-T cell therapy revolutionized treatment for various hematologic malignances. However, limited studies were reported...
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Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4+ T lymphocytes
BackgroundMesenchymal stromal cells (MSCs) isolated from the periodontal ligament (hPDL-MSCs) have a high therapeutic potential, presumably due to...
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Identification of Brain ECM Binding Variable Lymphocyte Receptors Using Yeast Surface Display
Extracellular matrix (ECM) is a rich mixture of proteins and glycans secreted by cells. This includes typical ECM structures such as collagen and...