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A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of...
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DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence of NAFLD has been...
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Epigenetic age acceleration is a distinctive trait of epithelioid sarcoma with potential therapeutic implications
Recently, DNA methylation clocks have been proven to be precise age predictors, and the application of these clocks in cancer tissue has revealed a...
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Causality-enriched epigenetic age uncouples damage and adaptation
Machine learning models based on DNA methylation data can predict biological age but often lack causal insights. By harnessing large-scale genetic...
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Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
BackgroundThe epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes in DNA methylation...
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Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications
BackgroundDNA analysis for forensic investigations has a long tradition with important developments and optimizations since its first application....
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Age-Related Variation in DNA Methylation
Methylation is a ubiquitous, naturally occurring biochemical modification of DNA in mammalian cells that regulates gene expression. DNA methylation...
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The relationship between epigenetic age and the hallmarks of aging in human cells
Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age at specific...
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Associations of seven measures of biological age acceleration with frailty and all-cause mortality among adult survivors of childhood cancer in the St. Jude Lifetime Cohort
Survivors of childhood cancer may experience accelerated biological aging, resulting in premature frailty and death. We used seven measures of...
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Pan-primate studies of age and sex
Age and sex have a profound effect on cytosine methylation levels in humans and many other species. Here we analyzed DNA methylation profiles of 2400...
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Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Physiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type...
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Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol
Targeting molecular processes of aging will enable people to live healthier and longer lives by preventing age-related diseases. Geroprotectors are...
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Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
BackgroundDNA methylation is an epigenetic mark associated with the repression of gene promoters. Its pattern in the genome is disrupted with age and...
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DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes
DNA methylation (DNAm) patterns across the genome changes during aging and development of complex diseases including type 2 diabetes (T2D). Our study...
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Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis
Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with...
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Heterogeneity of increased biological age in type 2 diabetes correlates with differential tissue DNA methylation, biological variables, and pharmacological treatments
Biological age (BA) closely depicts age-related changes at a cellular level. Type 2 diabetes mellitus (T2D) accelerates BA when calculated using...
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Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop
Biologic aging reflects the genetic, molecular, and cellular changes underlying the development of morbidity and mortality with advancing...