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The Generation and Recognition of Histone Methylation
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...
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A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
BackgroundOxidation Resistance 1 ( OXR1 ) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental...
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PRMT5-mediated regulatory arginine methylation of RIPK3
The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell...
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The role of histone methylation in renal cell cancer: an update
Renal cell carcinoma accounts for 2–3% of all cancers. It is difficult to diagnose early. Recently, genome-wide studies have identified that histone...
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TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation
Osteosarcoma (OS), the most common primary malignancy of the bone, has a poor prognosis due to its high mortality rate and high potential for...
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PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis
Many types of cancer cells, including colorectal cancer cells (CRC), can simultaneously enhance glycolysis and repress the mitochondrial...
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Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via...
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DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy
Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important...
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Development and Validation of Antibodies Targeting Site-Specific Histone Methylation
The development of specific anti-modification antibodies as research tools has revolutionized the way histone methylation is studied. Lack of...
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Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia
BackgroundThe symbiotic relationship between cnidarians and dinoflagellates is one of the most widespread endosymbiosis in our oceans and provides...
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DNA Methylation and Histone Modification in Dental-derived Mesenchymal Stem Cells
AbstractEpigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs (ncRNAs), is essential for the regulation...
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Histone Ubiquitylation and the Regulation of Transcription
The small (76 amino acids) and highly conserved ubiquitin protein plays key roles in the physiology of eukaryotic cells. Protein ubiquitylation...
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PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer
Overcoming distant metastasis stands as a paramount challenge in enhancing the outcomes of breast cancer treatments. Thus, delving deeper into...
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Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase
Histone lysine methyltransferase SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 lysine 20 (H4K20), has crucial...
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Profiling the Regulation of Histone Methylation and Demethylation by Metabolites and Metals
Here we describe how to profile the contribution of metabolism and implication of metals to histone methylation and demethylation. The techniques...
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The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
Physical activity on a regular basis has been shown to bolster the overall wellness of an individual; research is now revealing that these changes...
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Detection and Quantification of Histone Methyltransferase Activity In Vitro
Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues in histone as well as nonhistone substrates. In vitro...
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N(alpha)-acetyltransferase 40-mediated histone acetylation plays an important role in ecdysone regulation of metamorphosis in the red flour beetle, Tribolium castaneum
Histone acetylation, a crucial epigenetic modification, is governed by histone acetyltransferases (HATs), that regulate many biological processes....
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Not all Is SET for Methylation: Evolution of Eukaryotic Protein Methyltransferases
Dynamic posttranslational modifications to canonical histones that constitute the nucleosome (H2A, H2B, H3, and H4) control all aspects of enzymatic...
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DNA methylation and histone modifications induced by abiotic stressors in plants
BackgroundA review of research shows that methylation in plants is more complex and sophisticated than in microorganisms and animals. Overall,...