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The role of epigenetic modifiers in the hepatic differentiation of human umbilical cord derived mesenchymal stem cells
Human umbilical cord (hUC) derived mesenchymal stem cells (MSCs) can be progressively differentiated into multiple lineages including hepatic...
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In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment
Equine metabolic syndrome (EMS) is recognized as one of the leading cause of health threatening in veterinary medicine worldwide. Recently, PTP1B...
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Long noncoding RNA SNHG1 silencing accelerates hepatocyte-like cell differentiation of bone marrow-derived mesenchymal stem cells to alleviate cirrhosis via the microRNA-15a/SMURF1/UVRAG axis
Bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into hepatocyte-like cells (HLCs) to attenuate cirrhosis. Long noncoding RNA...
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Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals
Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a chemical response. Integrins are involved in the...
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Characteristics of mesenchymal stem cells and their exosomes derived from giant panda (Ailuropoda melanoleuca) endometrium
Conservation of genetic resources is an important way to protect endangered species. At present, mesenchymal stem cells (MSCs) have been isolated...
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Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells
BackgroundAmnion-derived mesenchymal stem cells (AM-MSCs) are an attractive source of stem cell therapy for patients with irreversible liver disease....
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Dexamethasone exposure during pregnancy triggers metabolic syndrome in offspring via epigenetic alteration of IGF1
BackgroundPrevious research has reported that prenatal exposure to dexamethasone (PDE) results in organ dysplasia and increased disease...
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Regenerative Potential of Human Breast Milk: A Natural Reservoir of Nutrients, Bioactive Components and Stem cells
Human milk is a complex fluid that contains carbohydrates, lipids, proteins, and other bioactive molecules (immunoglobulins, lactoferrin, human milk...
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Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency
BackgroundBiliary atresia (BA) is a severe hepatobiliary disease in infants that ultimately results in hepatic failure; however, its pathological...
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Adipose tissue-derived stem cells: a comparative review on isolation, culture, and differentiation methods
Adipose tissue-derived stem cells (ADSCs) are an available source of mesenchymal stem cells with the appropriate capacity to in vitro survive,...
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Dental Mesenchymal Stem/Progenitor Cells: A New Prospect in Regenerative Medicine
Dental mesenchymal stem/progenitor cells (MSCs) have unique biological criteria in terms of genes and protein expression. They possess the common...
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Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration
Toxic, viral and surgical injuries can pose medical indications for liver transplantation. The number of patients waiting for a liver transplant...
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Cell Sources for Tissue Engineering
One of the most essential elements of tissue engineering is the type of cell that is going to be used to regenerate a particular tissue. For this...
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Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review
Recently, mesenchymal stromal cells (MSCs) and their derivative exosome have become a promising approach in the context of liver diseases therapy, in...
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Adult stem cell sources for skeletal and smooth muscle tissue engineering
IntroductionTissue engineering is an innovative field with enormous developments in recent years. These advances are not only in the understanding of...
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Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury
Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only occurs in a dose-dependent manner but also occurs in some...
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Mesenchymal Stem Cell Differentiation Properties and Available Microenvironment
Mesenchymal stem cells (MSCs) have characteristic properties, the expression of which is being determined by the available microenvironment/niche....
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Cell heterogeneity, rather than the cell storage solution, affects the behavior of mesenchymal stem cells in vitro and in vivo
BackgroundMesenchymal stem cells (MSCs) have to be expanded in vitro to reach a sufficient cell dose for the treatment of various diseases. During...
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Combination of the modulators of epigenetic machinery and specific cell signaling pathways as a promising approach for cell reprogramming
During embryogenesis and further development, mammalian epigenome undergoes global remodeling, which leads to the emergence of multiple...
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Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune responses, induce acute or chronic liver injury, and 3.5% of all...
