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CARD8 Inflammasome Activation by HIV-1 Protease
The pattern recognition receptor CARD8 is an inflammasome sensor for intracellular HIV-1 protease activity. Previously, the only method for studying...
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Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy
CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living...
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HIV-1 Induced Cell-to-Cell Fusion or Syncytium Formation
HIV-1 cell-free infection has been thoroughly investigated; however, its relevance and importance in vitro are questionable. Cell-cell transmission...
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Transfer RNA modifications and DNA editing in HIV-1 reverse transcription
Reverse transcription is a central step in HIV-1 replication that represents a typical case of interplay between viral and cellular factors. HIV-1...
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Structural insights into PPP2R5A degradation by HIV-1 Vif
HIV-1 Vif recruits host cullin-RING-E3 ubiquitin ligase and CBFβ to degrade the cellular APOBEC3 antiviral proteins through diverse interactions....
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The Functions of N-methyladenosine (m6A) Modification on HIV-1 mRNA
In recent years, there has been a growing interest in the study of RNA modifications, with some researchers focusing specifically on the connection...
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Silencing Very-Low-Density Lipoprotein Receptor Reveals Alpha-1 Antitrypsin Role in HIV Infectivity
Here we describe methods for investigating alpha-1 antitrypsin (AAT) and very-low-density lipoprotein receptor (VLDLR) interactions with infectious...
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HIV-1 exploits Hes-1 expression during pre-existing HPV-16 infection for cancer progression
High Risk Human Papilloma Viruses (HR-HPV) persistently infect women with Human Immunodeficiency Virus-1 (HIV-1). HPV-16 escapes immune surveillance...
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In silico designing of novel epitope-based peptide vaccines against HIV-1
AbstractThe HIV-1 virus has been regarded as a catastrophe for human well-being. The global incidence of HIV-1-infected individuals is increasing....
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Employing computational tools to design a multi-epitope vaccine targeting human immunodeficiency virus-1 (HIV-1)
BackgroundDespite being in the 21 st century, the world has still not been able to vanquish the global AIDS epidemic, and the only foreseeable...
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Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
Successful approaches for eradication or cure of HIV-1 infection are likely to include immunological mechanisms, but remarkably little is known about...
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iTRAQ-based proteomic study on monocyte cell model discovered an association of LAMP2 downregulation with HIV-1 latency
BackgroundPatientswith immunodeficiency virus-1 (HIV-1) infection are challenging to be cured completely due to the existence of HIV-1 latency...
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Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev
Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5...
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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has...
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TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation
Binding of USF1/2 and TFII-I (RBF-2) at conserved sites flanking the HIV-1 LTR enhancer is essential for reactivation from latency in T cells, with...
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Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC) is pivotal in human immunodeficiency virus 1 (HIV-1)...
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Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1...
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Trap** the HIV-1 V3 loop in a helical conformation enables broad neutralization
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein trimer is indispensable for virus cell entry....
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Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As
Although the significance of chemical modifications on RNA is acknowledged, the evolutionary benefits and specific roles in human immunodeficiency...
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Data mining and molecular dynamics analysis to detect HIV-1 reverse transcriptase RNase H activity inhibitor
HIV-1 is a deadly virus that affects millions of people worldwide. In this study, we aimed to inhibit viral replication by targeting one of the HIV-1...
