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Generation of fluorescent HCV pseudoparticles to study early viral entry events- involvement of Rab1a in HCV entry
Understanding the early events in viral biology holds the key to the development of potent preventives. In this study, fluorescent hepatitis C virus...
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The signal-to-cutoff ratios to predict HCV infection among people who inject drugs
People who inject drugs (PWIDs) are primarily the high-risk population for HCV infection. This study aims to determine the optimal cut-off values for...
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Antimicrobial peptides: natural or synthetic defense peptides against HBV and HCV infections
According to the literature, treatment of HCV and HBV infections faces challenges due to problems such as the emergence of drug-resistant mutants,...
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Plasma Long Non-Coding RNA ZFAS1 as a Potential Diagnostic Biomarker for HCV-Related Hepatocellular Carcinoma
AbstractHepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide. Cirrhosis induced by hepatitis-C virus (HCV) infection is a...
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Current therapeutics against HCV
Hepatitis C is a positive stranded enveloped RNA virus belonging to the Flaviviridae family. HCV infection leads to severe liver diseases, cirrhosis...
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Natural flavonoids effectively block the CD81 receptor of hepatocytes and inhibit HCV infection: a computational drug development approach
Hepatitis C virus (HCV) infection is a major public health concern, and almost two million people are infected per year globally. This is occurred by...
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In silico drug repurposing for coronavirus (COVID-19): screening known HCV drugs against the SARS-CoV-2 spike protein bound to angiotensin-converting enzyme 2 (ACE2) (6M0J)
In this study, FDA-approved HCV antiviral drugs and their structural analogues—several of them in clinical trials—were tested for their inhibitory...
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Re-assessing the risk of undetected HBV, HCV and HIV in deceased tissue and living surgical bone donors in England
Testing of living surgical bone and deceased tissue donors by NHS Blood and Transplant (NHSBT) has included individual donation (ID) nucleic acid...
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Stability of a diffusive-delayed HCV infection model with general cell-to-cell incidence function incorporating immune response and cell proliferation
In this work, we analyse the dynamics of a five-dimensional hepatitis C virus infection mathematical model including the spatial mobility of...
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DFT, In Vitro Antimicrobial, HCV, HBV, HAV, and Breast Cancer Molecular Docking Exploration of 6-[(E)-(4-Hydroxy-2,5-dinitrophenyl)diazenyl]-2H-chromen-2-one and 6-[(E)-(10-Hydroxy-9-anthryl)diazenyl]-2H-chromen-2-one
AbstractObjective: The objective of this study was to investigate the 3D geometry optimization, theoretical spectroscopic features, chemical...
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The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silico
AbstractCoronavirus diseases 2019 (COVID-19) are seriously affecting human health all over the world. Nucleotide inhibitors have promising results in...
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Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression
Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our knowledge of their heterogeneity and dynamics within...
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Rapid, visual, label-based biosensor platform for identification of hepatitis C virus in clinical applications
ObjectivesIn the current study, for the first time, we reported a novel HCV molecular diagnostic approach termed reverse transcription loop-mediated...
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Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
Direct acting antivirals (DAAs) have been developed for hepatitis C virus (HCV) therapy, and they are usually effective, however resistance to DAA...
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Cross talk between alcohol-induced oxidative stress and HCV replication
Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV) infection and aggravates disease consequences in alcohol‐abusing...
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Impact of IL28 Genotypes and Modeling the Interactions of HCV Core Protein on Treatment of Hepatitis C
BackgroundMutations in the core CVR region of hepatitis C virus (HCV) and polymorphisms of interleukin 28B (IL28B) are associated with...
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Targeting ER stress/PKA/GSK-3β/β-catenin pathway as a potential novel strategy for hepatitis C virus-infected patients
BackgroundChronic hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC). The HCC risk, while decreased compared with active HCV...
