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A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a...
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New pAraDH2 Promoter for Metabolic Engineering of the Yarrowia lipolytica Yeast
AbstractThe ability to utilize a number of polyhydric alcohols as a sole carbon source has been studied in the Yarrowia lipolytica yeast. The...
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Use of the Saccharomycopsis schoenii MET17 promoter for regulated heterologous gene expression
The ability to regulate the expression of genes is a central tool for the characterization of fungal genes. This is of particular interest to study...
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DNA methyltransferase 3a-induced hypermethylation of the fructose-1,6-bisphosphatase-2 promoter contributes to gastric carcinogenesis
BackgroundAberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that...
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Promoter replication of grape MYB transcription factor is associated with a new red flesh phenotype
Key messageIn our study, we discovered a fragment duplication autoregulation mechanism in ‘ZS-HY’, which may be the reason for the phenotype of red...
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Nutrient limitation and oxidative stress induce the promoter of acetate operon in Salmonella Typhimurium
Glyoxylate shunt is an important pathway for microorganisms to survive under multiple stresses. One of its enzymes, malate synthase (encoded by aceB ...
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Functional characterization of the Komagataella phaffii 1033 gene promoter and transcriptional terminator
The methylotrophic yeast Komagataella phaffii (syn. Pichia pastoris ) is a widely used host for extracellularly producing heterologous proteins via an...
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Identification of the Core Promoter Region of Human Foxg1 Gene
AbstractForkhead box G1 (FOXG1) is a transcriptional repressor with high expression in the nervous system. Most research focused on the biological...
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Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer
BackgroundPreviously, we reported lower RSK4 mRNA and protein levels in malignant ovarian tumors compared to normal and benign ovarian tissues. Also,...
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PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including...
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Functional characterization of GhNAC2 promoter conferring hormone- and stress-induced expression: a potential tool to improve growth and stress tolerance in cotton
The GhNAC2 transcription factor identified from G. herbaceum improves root growth and drought tolerance through transcriptional reprogramming of...
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Repressible Promoter System to Study Essential Genes in Mycobacteria
Inducible gene expression systems represent powerful tools for studying essential gene function and for validation of drug targets in bacteria. Even...
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Cloning and functional analysis of the promoter of a UDP-glycosyltransferase gene from Panax quinquefolium L.
Pq3-O-UGT2 is a key UDP-glycosyltransferase gene in the ginsenoside biosynthesis pathway of Panax quinquefolium L. Functional analysis of promoter...
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A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells
BackgroundGenome-wide association studies (GWAS) have identified genetic variants linked to fat metabolism and related traits, but rarely pinpoint...
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Expanding the promoter toolbox for metabolic engineering of methylotrophic yeasts
AbstractMethylotrophic yeasts have been widely recognized as a promising host for production of recombinant proteins and value-added chemicals....
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Identification and promoter analysis of a GA-stimulated transcript 1 gene from Jatropha curcas
Key messageOverexpression of JcGAST1 promotes plant growth but inhibits pistil development. The pyrimidine box and CGTCA motif of the JcGAST1 ...
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Promoter of Nitrate Reductase Gene Behaves Differently Under Salinity Stress in Contrasting Rice Genotype
Soil salinity is a global agricultural issue that decreases both plant production and survival. Plants synthesize secondary nitrogen metabolites,...
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Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR
The lifetime risk of kidney disease in people with diabetes is 10–30%, implicating genetic predisposition in the cause of diabetic kidney disease...
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G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer
P38γ (MAPK12) is predominantly expressed in triple negative breast cancer cells (TNBC) and induces stem cell (CSC) expansion resulting in decreased...
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Sub-operon promoter arrangement of disA facilitates c-di-AMP homeostasis and selective stress responses in Mycobacterium smegmatis
Bacterial second messenger signaling often plays an important role in cellular physiology. In this study, we have attempted to understand how...
