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TLR3-mediated Astrocyte Responses in High and Normal Glucose Adaptation Differently Regulated by Metformin
Toll-like receptors 3 (TLR3) are innate immune receptors expressed on a wide range of cell types, including glial cells. Inflammatory responses...
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Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation
Neuronal activity creates an intense energy demand that must be met by rapid metabolic responses. To investigate metabolic adaptations in the...
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Skeletal muscle cells opto-stimulation by intramembrane molecular transducers
Optical stimulation and control of muscle cell contraction opens up a number of interesting applications in hybrid robotic and medicine. Here we show...
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Functional Assays in 3D ObaCell® Fat-on-a-Chip Cultures: Lipolysis and Glucose Uptake Assays
Advancements in three-dimensional in vitro cultures pose a need for modification of established two-dimensional culture functional assay methods....
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Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival
Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose...
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Pancreatic microexons regulate islet function and glucose homeostasis
Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and their abnormal function causes diabetes or...
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Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion
Biphasic glucose-stimulated insulin secretion (GSIS) is essential for blood glucose regulation, but a mechanistic model incorporating the recently...
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The role of GLUT2 in glucose metabolism in multiple organs and tissues
The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute...
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The glucose transporter 2 regulates CD8+ T cell function via environment sensing
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and...
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Adaptation of Glucose Metabolism to Limb Autotomy and Regeneration in the Chinese Mitten Crab
Limb autotomy and regeneration represent distinctive responses of crustaceans to environmental stress. Glucose metabolism plays a pivotal role in...
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O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
Although insulin mediated glucose uptake in skeletal muscle is a major mechanism ensuring glucose disposal in humans, glucose effectiveness, i.e.,...
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Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL
Metabolic crosstalk of the major nutrients glucose, amino acids and fatty acids (FAs) ensures systemic metabolic homeostasis. The coordination...
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Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice
Nutritional status and pyroptosis are important for host defence against infections. However, the molecular link that integrates nutrient sensing...
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High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction
Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N 6 -methyladen...
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α1-Adrenergic Stimulation Increases Platelet Adhesion to Endothelial Cells Mediated by TRPC6
Stimulation of a1-adrenergicAdrenergic nervous systemNervous system is increased during systemic inflammationInflammation and other pathological...
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AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth in response to amino acid and glucose levels. However, how mTORC1 senses...
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Bruton tyrosine kinase degrader BP001 attenuates the inflammation caused by high glucose in raw264.7 cell
BP001 is a promising small molecule compound that has been specifically designed to target and degrade Bruton's tyrosine kinases (BTK), which is...
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Modulation of gene expression in immune-related organs by in ovo stimulation with probiotics and prophybiotics in broiler chickens
In ovo stimulation has been studied intensively as an alternative to antibiotic use in poultry production. We investigated the potential use of a...
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Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats
Proteins activate small intestinal calcium sensing receptor (CaSR) and/or peptide transporter 1 (PepT1) to increase hormone secretion
1 –8 , but the...
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Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo
Cellular glucose uptake is a key feature reflecting metabolic demand of cells in physiopathological conditions. Fluorophore-conjugated sugar...
