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Identification and characterization of globin gene from Bombus terrestris (Hymenoptera: Apocrita: Apidae)
Hemoglobins are mainly functional in the transport and storage of O 2 , and are present in aerobic, lung respiratory metazoans. Based on recent...
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Segregation of α- and β-Globin Gene Cluster in Vertebrate Evolution: Chance or Necessity?
AbstractThe review is devoted to the patterns of evolution of α- and β-globin gene domains. A hypothesis is presented according to which segregation...
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Investigation of the mechanism of copy number variations involving the α-globin gene cluster on chromosome 16: two case reports and literature review
Thalassemia is one of the most common single-gene disorder worldwide. An important genetic cause of thalassemia is copy number variations (CNVs) in...
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Ancestry of the major long-range regulatory site of the α-globin genes in the Portuguese population with the common 3.7 kb α-thalassemia deletion
BackgroundThe α-Major Regulatory Element (α-MRE), also known as HS-40, is located upstream of the α-globin gene cluster and has a crucial role in the...
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Overexpression of a soybean Globin (GmGlb1-1) gene reduces plant susceptibility to Meloidogyne incognita
Main conclusionThe overexpression of the GmGlb1-1 gene reduces plant susceptibility to Meloidogyne incognita .
AbstractNon-symbiotic globin class #1 ...
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Evolutionary analysis of globin domains from kinetoplastids
Globin (Gb) domains function in sensing gaseous ligands like oxygen and nitric oxide. In recent years, Gb domain containing heme binding adenylate...
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Analysis of δ-globin gene alleles in Tunisians: description of three new delta-thalassemia mutations
BackgroundThalassemia is one of the most prevalent worldwide autosomal recessive disorders characterized by a great molecular and clinical expression...
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CRISPR Activator Approaches to Study Endogenous Androglobin Gene Regulation
Androglobin (ADGB), the most recently identified member of the mammalian globin family, is a chimeric protein with an unusual, embedded globin domain...
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Molecular evolution of the hemoglobin gene family across vertebrates
Adaptation to various altitudes and oxygen levels is a major aspect of vertebrate evolution. Hemoglobin is an erythrocyte protein belonging to the...
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Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A
BackgroundHuman erythropoiesis is a tightly regulated, multistep process encompassing the differentiation of hematopoietic stem cells (HSCs) toward...
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Comparative evaluation for the globin gene depletion methods for mRNA sequencing using the whole blood-derived total RNAs
BackgroundThere are challenges in generating mRNA-Seq data from whole-blood derived RNA as globin gene and rRNA are frequent contaminants. Given the...
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Epigenetic Control of Gene Expression
Genetic mutations lead to inheritable changes in the traits. Alterations in genetic features may also be caused by chromatin modifications without...
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Gene korrigieren
Viele heutigen Therapien für genetische Krankheiten zielen darauf ab, die Schwere der Symptome zu reduzieren und die Lebensqualität zu verbessern,...
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Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation
Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established...
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PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients’ RBCs ex vivo in the frame of Protein Replacement Therapy
Backgroundα-Thalassemia, a congenital hemoglobinopathy, is characterized by deficiency and/or reduced levels of α-globin chains in serious forms of...
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Biomanufacturing Aspects of Gene Therapy
The notion that genetic material could be transferred to a host patient for therapeutic benefit has been around for over half a century. However, it...
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Reminiscences on Positional Cloning of X-CGD Gene (Aka CYBB, gp91phox, Nox2)
In 1986 my laboratory reported the cloning of the gene that encodes the protein mutated in the X-linked form of chronic granulomatous disease...
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Base Editors-Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases
Base editors, developed from the CRISPR/Cas system, consist of components such as deaminase and Cas variants. Since their emergence in 2016, the...
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Viral Vectors in Gene Replacement Therapy
AbstractThroughout the years, several hundred million people with rare genetic disorders have been receiving only symptom management therapy....
