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Genomic Instability
Maintenance of genome stability is vital for human health, and it is of particular importance in ageing. Genome stability is regulated by multiple...
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Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential...
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BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination
Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in...
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PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown...
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Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families
The aging process, or senescence, is characterized by age-specific decline in physical and physiological function, and increased frailty and genomic...
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Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?
Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the tumor suppressor protein p53. Genetically modified...
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DNA Isolation Long-Read Genomic Sequencing in Ctenophores
Long-read sequencing has proven the necessity for high-quality genomic assemblies of reference species, including enigmatic ctenophores. Obtaining...
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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans
Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship...
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Extraction of genomic DNA for sequencing from snail Helix lucorum
Genomic studies make it possible to breakthrough in many fields such as biochemistry, physiology, phylogenetics, etc., though they are unworkable...
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Chromatin dynamics and RNA metabolism are double-edged swords for the maintenance of plant genome integrity
Maintenance of genome integrity is an essential process in all organisms. Mechanisms avoiding the formation of DNA lesions or mutations are well...
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Novel regulators of mitochondrial genome integrity
Mitochondrial genomes are unusual in that they have very low mutation rates in coding sequences when compared with animals, yeast, and bacteria. It...
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Genomic instability in individuals with sex determination defects and germ cell cancer
The ability to transmit genetic information through generations depends on the preservation of genome integrity. Genetic abnormalities affect cell...
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Principles of Genomic Evolution
In the preceding chapters, we looked at a possible topological model of genomic architecture. Even if we were to accept the proposed model to be true...
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Antimicrobial activity of phenyllactic acid against Klebsiella pneumoniae and its effect on cell wall membrane and genomic DNA
As Klebsiella pneumoniae (KP) has acquired high levels of resistance to multiple antibiotics, it is considered a worldwide pathogen of concern, and...
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A rapid, inexpensive and effective method for the efficient isolation of genomic DNA from Gram-negative bacteria
Currently, there are several protocols to extract bacterial DNA based on different principles. However, the quantity and the quality of the DNA...
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Best practices for genetic and genomic data archiving
Genetic and genomic data are collected for a vast array of scientific and applied purposes. Despite mandates for public archiving, data are typically...
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Altering Escherichia coli envelope integrity by mimicking the lipoprotein RcsF
Escherichia coli cell envelope is crucial for stress sensing and signal transduction, mediated by numerous protein–protein interactions to enable...
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Managing genomic diversity in conservation programs of Chinese domestic chickens
BackgroundEffective conservation and utilization of farm animals are fundamental for realizing sustainable increases in food production. In situ and...
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EvoAug: improving generalization and interpretability of genomic deep neural networks with evolution-inspired data augmentations
Deep neural networks (DNNs) hold promise for functional genomics prediction, but their generalization capability may be limited by the amount of...
