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Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets
Polyglutamine (PolyQ) diseases include a group of inherited neurodegenerative disorders caused by unstable expansions of CAG trinucleotide repeats in...
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Fine map** and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8
Dravet syndrome is a developmental and epileptic encephalopathy (DEE) characterized by intractable seizures, comorbidities related to developmental,...
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Gabra2 is a genetic modifier of Dravet syndrome in mice
Pathogenic variants in epilepsy genes result in a spectrum of clinical severity. One source of phenotypic heterogeneity is modifier genes that affect...
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Genetic Interaction, Epistasis, Modifiers
Biological processes in an organism are interconnected and regulated by a network of genes. Therefore, the genetic dissection of their functional...
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Fine map** and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11
Pathogenic variants in SCN1A result in a spectrum of phenotypes ranging from mild febrile seizures to Dravet syndrome, a severe infant-onset...
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Genetic Improvement of Industrial Crops Through Genetic Engineering
Genetic engineering is one of the modern biotechnology techniques that allows the transfer of genes between unrelated genera or species. It is being...
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Whole genome sequencing facilitates intragenic variant interpretation following modifier screening in C. elegans
BackgroundIntragenic modifiers (in-phase, second-site variants) are known to have dramatic effects on clinical outcomes, affecting disease attributes...
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The improvement of the in vitro plant regeneration in barley with the epigenetic modifier of histone acetylation, trichostatin A
Genotype-limited plant regeneration is one of the main obstacles to the broader use of genetic transformation in barley breeding. Thus, develo**...
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Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes (Ras homolog enriched in the striatum), a multifunctional protein that regulates striatal functions associated with motor behaviors and...
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Super Sweet and Taste Modifier Proteins
It has been found that super sweet (SS) proteins are thousands times sweeter than sucrose, required in a very small amount to sweeten the food...
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Update in genetic and epigenetic causes of hypertension
Hypertension is a heritable disease that affects one-fourth of the population and accounts for about 50% of cardiovascular deaths. The genetic basis...
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Exploring the role of symbiotic modifier peptidases in the legume − rhizobium symbiosis
Legumes can establish a mutual association with soil-derived nitrogen-fixing bacteria called ‘rhizobia’ forming lateral root organs called root...
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Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse
Several lines of evidence suggest that the presence of the Y chromosome influences DNA methylation of autosomal loci. To better understand the impact...
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A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens
Map** genetic interactions is essential for determining gene function and defining novel biological pathways. We report a simple to use CRISPR...
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A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization
Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote...
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Unveiling the population genetic structure of Iranian horses breeds by whole-genome resequencing analysis
Preserving genetic diversity is pivotal for enhancing genetic improvement and facilitating adaptive responses to selection. This study focuses on...
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Genetic diversity and recent ancestry based on whole-genome sequencing of endangered Swedish cattle breeds
Several indigenous cattle breeds in Sweden are endangered. Conservation of their genetic diversity and genomic characterization is a priority.
Whole-ge...
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Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s)
Choreoacanthocytosis, one of the forms of neuroacanthocytosis, is caused by mutations in vacuolar protein sorting-associated protein A ( VPS13A ), and...
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Genetic Improvement of Specialty Corn for Nutritional Quality Traits
Specialty corn has emerged as a preferred choice as food, feed, and various industrial products due to its diverse usage. Among the various types,...
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Genetic analysis of flower colour variation in periwinkle (Catharanthus roseus L.) inbred lines
Periwinkle ( Catharanthus roseus L.) is an ornamental and therapeutic herbaceous subshrub. The available literature on inheritance of flower colour in...
