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Integration of DNA Microarray with Clinical and Genomic Data
DNA microarrays have been widely employed to understand cancer development. This technology is able to measure expression levels of a large numbers...
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Comparing preprocessing strategies for 3D-Gene microarray data of extracellular vesicle-derived miRNAs
BackgroundExtracellular vesicle-derived (EV)-miRNAs have potential to serve as biomarkers for the diagnosis of various diseases. miRNA microarrays...
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Metabolic function-based normalization improves transcriptome data-driven reduction of genome-scale metabolic models
Genome-scale metabolic models (GEMs) are extensively used to simulate cell metabolism and predict cell phenotypes. GEMs can also be tailored to...
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Exosomal Mir-3613-3p derived from oxygen–glucose deprivation-treated brain microvascular endothelial cell promotes microglial M1 polarization
BackgroundBrain microvascular endothelial cell (BMEC) injury can affect neuronal survival by modulating immune responses through the...
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Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity
Immortalization-upregulated protein (IMUP) plays a vital role in cell proliferation and tumor progression. However, its role in pancreatic ductal...
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Genome-wide characterization and expression analysis of the HAK gene family in response to abiotic stresses in Medicago
The high-affinity K + transporter (HAK) family plays a vital role in K + uptake and transport as well as in salt and drought stress responses. In the...
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Mining transcriptome data to identify genes and pathways related to lemon taste using supervised and unsupervised data learning methods
There is a dearth of studies on the genes engaged in citrus taste. Unraveling the major genes involved in pathways related to the taste of citrus...
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Toxicity Analysis of Pentachlorophenol Data with a Bioinformatics Tool Set
Rapid progress in technologies opened the new era of computer-leaded analytics, leaving humans more space for experimental design and decision...
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Extracellular vesicles derived from human Sertoli cells: characterizations, proteomic analysis, and miRNA profiling
BackgroundExtracellular vesicles (EVs) contain thousands of proteins and nucleic acids, playing an important role in cell–cell communications....
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Effects of sustained hyperprolactinemia in late gestation on the mammary parenchymal tissue transcriptome of gilts
BackgroundGilts experiencing sustained hyperprolactinemia from d 90 to 109 of gestation showed an early onset of lactogenesis coupled with premature...
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Databases and Bioinformatics Tools for Data Mining
Data, information, and knowledge play an interesting role in human life. Huge repositories of data generated because of the recent development of...
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Pollen Development, a Genetic and Transcriptomic View
The haploid gametophyte generation occupies a short but vital phase in the life cycle of flowering plants. The male gametophyte consists of just...
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A comparison of the TempO-Seq and Affymetrix microarray platform using RTqPCR validation
Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as...
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Exosomes enriched by miR-429-3p derived from ITGB1 modified Telocytes alleviates hypoxia-induced pulmonary arterial hypertension through regulating Rac1 expression
BackgroundRecent studies have emphasized the critical role of Telocytes (TCs)-derived exosomes in organ tissue injury and repair. Our previous...
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Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity
Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies...
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Topology of RNA:DNA Hybrids and R-Loops in Yeast
RNA:DNA hybrids are generated naturally behind the elongating RNA polymerase as a transcriptional intermediate. However, prolonged persistence of...
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Understanding of Root Nodule Development at Level of System Biology as Obtained by High Throughput Transcriptomic Approach
Nodule development starts with dedifferentiation of the already differentiated root tissues. Dedifferentiation involves a complex but finely tuned,...
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GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the...
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Global miRNA expression of bone marrow mesenchymal stem/stromal cells derived from Fanconi anemia patients
Fanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, developmental defects, and bone marrow (BM) failure....
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Micro-array Analysis of Cold Tolerant Tomato Expressing Nicotiana tabacum Osmotin
Our earlier studies have established improved cold tolerance in the transgenic tomato ( Solanum lycopersicum cv. Pusa Ruby) developed through...
