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Cytometry in High-Containment Laboratories
The emergence of new pathogens continues to fuel the need for advanced high-containment laboratories across the globe. Here we explore challenges and...
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Efficient evaluation of a gene containment system for poplar through early flowering induction
Key messageThe early flowering system HSP:: AtFT allowed a fast evaluation of a gene containment system based on the construct PsEND1:: barnase–barstar ...
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Investigating Pseudomonas aeruginosa Gene Function During Pathogenesis Using Mobile-CRISPRi
CRISPR interference (CRISPRi) is a robust gene silencing technique that is ideal for targeting essential and conditionally essential (CE) genes....
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Plant Tissue Culture: A Boon or Enigma in Gene Editing for Plants Using CRISPR/Cas System
This chapter delves into the exploration of metabolic pathways, unraveling cellular activities, genetic enhancement, and the production of...
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Induction of new allelic variant of AhFAD2B gene in peanut cultivar, GG20 through CRISPR/Cas9-mediated mutagenesis
The ratio of oleic acid to linoleic acid (O/L) is crucial for determining the shelf life of peanut oil. In peanuts, the expression of the Fatty Acid...
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Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries
The neglected and rare zoonotic disease caused by monkeypox virus (MPV) has recently spread widely, resulting in the largest known monkeypox outbreak...
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Metalign: efficient alignment-based metagenomic profiling via containment min hash
Metagenomic profiling, predicting the presence and relative abundances of microbes in a sample, is a critical first step in microbiome analysis....
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Enhancing rice grain quality through the knock-out of the OsSPL16 gene
The OsSPL16 (SQUAMOSA promoter-binding protein like 16) or GW8 ( Grain Width 8 ) gene is expressed specifically in develo** seeds and positively...
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Virus-Induced Gene Silencing in Wheat and Related Monocot Species
Advances made in genome sequencing projects and structural genomics are generating large repertoire of candidate genes in plants associated with...
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Regulatory Aspects of Cell and Gene Therapy Products: The Japanese Perspective
Regulations for regenerative medicine for human use, such as cell and gene therapy (CGT), have evolved in accordance with advancements in clinical...
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(Trans)Gene Flow: Mechanisms, Biosafety Concerns and Mitigation for Containment
Rapid progress in genetic engineering of plants has opened vistas for manipulation of traits to not only meet the ever-increasing need of food, feed,...
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Overexpression of phosphoenol pyruvate carboxylase gene of Flaveria trinervia in transgenic mulberry (Morus spp.) leads to improved photosynthesis rate and tolerance to drought and salinity stresses
This study developed three transgenic mulberry lines containing heterologous phosphoenol pyruvate carboxylase gene of Flaveria trinervia through Agroba...
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The Regulation of Cell Therapy and Gene Therapy Products in Switzerland
This chapter describes the regulation of cell and gene therapy products (CGTPs) in Switzerland and its legal basis. The Swiss Agency for Therapeutic...
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Regulation of Clinical Research for Cellular and Gene Therapy Products in India
The understanding of disease biology and advances in cellular and molecular biology platforms have ushered in a new era of cell and gene based...
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Artificial coat protein variants of cucumber mosaic virus induce enhanced resistance upon recognition by an R gene
Induction of R -gene-mediated antiviral resistance results in phenotypically different responses depending on host R gene—virus combinations. The...
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Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models
Pulmonary arterial hypertension (PAH) is a severe and progressive cardiopulmonary disease characterized by pathological remodeling of the resistance...
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Applications of Gene Drive for Weeds and Pest Management Using CRISPR/Cas9 System in Plants
Solutions to world hunger include addressing the challenge of agricultural losses due to weeds and pests. New crop varieties which possess herbicide...
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Plant death caused by inefficient induction of antiviral R-gene-mediated resistance may function as a suicidal population resistance mechanism
Land plant genomes carry tens to hundreds of Resistance ( R ) genes to combat pathogens. The induction of antiviral R -gene-mediated resistance often...
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Cleave and Rescue gamete killers create conditions for gene drive in plants
Gene drive elements promote the spread of linked traits and can be used to change the composition or fate of wild populations. Cleave and Rescue ( ClvR ...
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Canadian Regulatory Framework and Regulatory Requirements for Cell and Gene Therapy Products
Health Canada regulates gene therapy products and many cell therapy products as biological drugs under the Canadian Food and Drugs Act and its...