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Methylation mediated Gadd45β enhanced the chemosensitivity of hepatocellular carcinoma by inhibiting the stemness of liver cancer cells
BackgroundDefects of the growth arrest DNA damage-inducible gene 45β (Gadd45β) play an important role in the progression of tumor and confer...
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OsGADD45a1: a multifaceted regulator of rice architecture, grain yield, and blast resistance
Key messageThe homolog gene of the Growth Arrest and DNA Damage-inducible 45 (GADD45) in rice functions in the regulation of plant architecture,...
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Transcriptome analysis revealed gene expression feminization of testis after exogenous tetrodotoxin administration in pufferfish Takifugu flavidus
Tetrodotoxin (TTX) is a deadly neurotoxin and usually accumulates in large amounts in the ovaries but is non-toxic or low toxic in the testis of...
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Oxidative Stress and Redox-Dependent Signaling in Prostate Cancer
AbstractTumor emergence and progression is complicated by the dual role of reactive oxygen species (ROS). Low concentrations of ROS are essential for...
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The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair
In the cartilage matrix, complex interactions occur between angiogenic and anti-angiogenic components, growth factors, and environmental stressors to...
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Active DNA Demethylation in Development, Human Disease, and Cancer
Methylation of cytosine in DNA has long been known as an important mechanism of transcriptional regulation. While DNA methyltransferases have been...
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Mitogen-Activated Protein Kinase Signaling and Cancer
The mitogen-activated protein kinase (MAPK) signaling pathways consist of a three-tiered core of sequentially activated protein kinases, namely, MAPK...
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Col10a1 gene expression and chondrocyte hypertrophy during skeletal development and disease
The type X collagen gene, COL10A1 , is specifically expressed by hypertrophic chondrocytes during endochondral ossification. Endochondral ossification...
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Epigenetic choreography of stem cells: the DNA demethylation episode of development
Reversible DNA methylation is a fundamental epigenetic manipulator of the genomic information in eukaryotes. DNA demethylation plays a very...
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TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition
Over time, TGF-β has emerged as both a tumor promoter and a tumor suppressor, depending on the cell type. Although it was first characterized as...
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Estrogen Receptor—Tumor Suppressor Protein p53 Signaling Crosstalk as Potential Targets of Xenoestrogens
Excessive exposure to endogenous estrogens can lead to adverse health effects including higher risk for diseases such as breast cancer. Many...
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Hypermethylation of growth Arrest DNA-damage-inducible gene 45 in non-small cell lung cancer and its relationship with clinicopathologic features
The growth arrest DNA-damage-inducible protein 45 (GADD45) can serve as a key coordinator of the stress response by regulating cell cycle...
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Apoptosis and aging: increased resistance to apoptosis enhances the aging process
Apoptosis is a vital component in the evolutionarily conserved host defense system. Apoptosis is the guardian of tissue integrity by removing unfit...
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AP-1 as a regulator of cell life and death
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking...
