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GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis
Nonalcoholic fatty liver disease (NAFLD) is characterised by hepatic steatosis, inflammation, and insulin resistance. The role of long noncoding RNA...
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LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis
Long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) has been shown to be a regulator for many cancers, including non-small cell...
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NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis
Interactions of tumor cells with immune cells in the tumor microenvironment play an important role during malignancy progression. We previously...
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LncRNA-GAS5/miR-382-3p axis inhibits pulmonary artery remodeling and promotes autophagy in chronic thromboembolic pulmonary hypertension
BackgroundWe have clarified the role of miR-382-3p in chronic thromboembolic pulmonary hypertension (CTEPH), but what is less clear lies in its...
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GAS5/METTL14/ESR1 genetic variants are related to the susceptibility of coronary heart disease
The prevention and treatment of coronary heart disease (CHD) is a difficult problem to be solved urgently. Genetic factors play a crucial role in CHD...
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GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis
BackgroundAsthma is a serious respiratory disease that affects the physical and mental health of children. Airway epithelial apoptosis concomitantly...
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Long non-coding RNA GAS5 suppresses rheumatoid arthritis progression via miR-128-3p/HDAC4 axis
Rheumatoid arthritis (RA) is a highly relevant public health problem. RA fibroblast-like synoviocytes (RAFLSs) play an important role in RA...
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Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress
Organelles use specialized molecules to regulate their essential cellular processes. However, systematically elucidating the subcellular distribution...
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GAS5 knockdown suppresses inflammation and oxidative stress induced by oxidized low-density lipoprotein in macrophages by sponging miR-135a
A large number of long non-coding RNAs have been confirmed to play vital roles in regulating various biological processes. Abnormal expression of...
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Low GAS5 expression may predict poor survival and cisplatin resistance in cervical cancer
Cisplatin resistance is a major challenge in cervical cancer (CC) chemotherapy. Growth arrest‐specific 5 (GAS5) has been reported to be a tumour...
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The lncRNA GAS5 Inhibits the Osteogenic Differentiation and Calcification of Human Vascular Smooth Muscle Cells
Vascular calcification (VC), which is associated with high cardiovascular morbidity and mortality in patients with chronic kidney disease, is...
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LncRNA GAS5 promotes apoptosis as a competing endogenous RNA for miR-21 via thrombospondin 1 in ischemic AKI
Mounting evidence has indicated that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) played important roles in renal ischemia/reperfusion (I/R)...
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LncRNA GAS5-AS1 inhibits glioma proliferation, migration, and invasion via miR‐106b-5p/TUSC2 axis
Glioma is one of the most common malignant tumors and shows a high metastasis rate and poor prognosis. Abnormal expression of long non-coding RNAs...
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lncRNAs dysregulation in monocytes from primary antiphospholipid syndrome patients: a bioinformatic and an experimental proof-of-concept approach
BackgroundAntiphospholipid syndrome (APS) is the main cause of acquired thrombophilia where peripheral circulating cells such as monocytes have a key...
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Downregulation of LncRNA GAS5 promotes liver cancer proliferation and drug resistance by decreasing PTEN expression
Accumulating evidence has shown that the long noncoding RNAs (lncRNAs) play a crucial role in the regulation of hepatocellular carcinoma (HCC)...
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Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling
The long noncoding RNA growth-arrest specific 5 (GAS5) is a suppressor of many cancers. However, the role and mechanism of action of GAS5 in...
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Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in breast cancer patients: analysis by 1H NMR spectroscopy and RT-q-PCR
IntroductionGlobally, one of the major causes of cancer related deaths in women is breast cancer. Although metabolic pattern is altered in cancer...
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Non-coding RNAs Related to Cardiometabolic Diseases and Associated to Cancer
Low miR-1, miR-7, miR-17, miR-26a, miR-29a, miR-30a, miR-34a, miR-124, miR-133, miR-143-145, miR-150, miR-378, miR-455, lincRNA-p21, and MEG3 are...
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Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study
BackgroundIschemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis,...
