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The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When...
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Influence of Light of Different Narrowband Light on the Key of Calvin Cycle and Antioxidant Enzyme, Secondary Metabolites and Microbial Communities in Soybeans
AbstractLight is essential for plant growth, although excessive light radiation may have negative effects on many plants, including soybeans. This...
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A non-carboxylating pentose bisphosphate pathway in halophilic archaea
Bacteria and Eucarya utilize the non-oxidative pentose phosphate pathway to direct the ribose moieties of nucleosides to central carbon metabolism....
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Regulatory Mechanisms of Photosynthetic CO2 Fixation in Unicellular Microbes
Aquatic photoautotrophs, such as microalgae and cyanobacteria, contribute 50% of carbon assimilated into organic matter through their carbon fixation...
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Identification of Fusarium-induced stress protein (FISP) in wheat: characterization and localization
7 d old germinated wheat ( Triticum aestivum Var. Sonalika) seedlings infected with Fusarium oxysporum spores for a period of 7 d revealed an...
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Targeting a moonlighting function of aldolase induces apoptosis in cancer cells
Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme...
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Effect of the hps/phi Copy Number on the Growth of Methylococcus capsulatus MIR
Abstract —Methylococcus capsulatus MIR is a biotechnologically promising strain of methanotrophic bacteria for obtaining feed protein and other...
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Candidatus Enterousia, Bacteria with Reduced Genomes from the Intestines of Farm Animals
AbstractAs a result of metagenomic analysis of feces of farm animals, 5 genomes of alpha-proteobacteria of the candidate genus Enterousia of the...
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An insight into differential protein abundance throughout Leishmania donovani promastigote growth and differentiation
Leishmania donovani causes anthroponotic visceral leishmaniasis, responsible for about 50,000 annual deaths worldwide. Current therapies have...
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Metabolic Modules, Pathways, and Nodes of Intermediates
The prototypic enzymatic reactions introduced in Chap. 7 are shown in this chapter as they combine and function...
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Time-course analysis of Streptococcus sanguinis after manganese depletion reveals changes in glycolytic and nucleic acid metabolites
IntroductionManganese is important for the endocarditis pathogen Streptococcus sanguinis . Little is known about why manganese is required for...
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Respiration
Energy required for growth as well as for functions in all living beings is met through ATP generated during respiration. Additionally, in green...
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Intercrop** improves faba bean photosynthesis and reduces disease caused by Fusarium commune and cinnamic acid-induced stress
Modern intensive crop** systems often contribute to the accumulation of phenolic acids in the soil, which promotes the development of soilborne...
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The metal cofactor: stationary or mobile?
AbstractMetal cofactors are essential for catalysis and enable countless conversions in nature. Interestingly, the metal cofactor is not always...
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Screening Microbial Interactions During Inulin Utilization Reveals Strong Competition and Proteomic Changes in Lacticaseibacillus paracasei M38
Competition for resources is a common microbial interaction in the gut microbiome. Inulin is a well-studied prebiotic dietary fiber that profoundly...
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Antagonism of tomato spotted wilt virus against tomato yellow leaf curl virus in Nicotiana benthamiana detected by transcriptome analysis
BackgroundTomato spot wilt virus (TSWV) and tomato yellow leaf curl virus (TYLCV) are highly harmful viruses in agricultural production, which can...
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Deletion of lacD gene affected stress tolerance and virulence of Streptococcus suis serotype 2
Streptococcus suis type 2 ( S. suis type 2, SS2), an infectious pathogen which is zoonotic and can induce severely public health concern. Our previous...
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Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways
Metabolic reprogramming is a core hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). Here we show that hepatic...
