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CARE 2.0: reducing false-positive sequencing error corrections using machine learning
BackgroundNext-generation sequencing pipelines often perform error correction as a preprocessing step to obtain cleaned input data. State-of-the-art...
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Sequencing introduced false positive rare taxa lead to biased microbial community diversity, assembly, and interaction interpretation in amplicon studies
BackgroundIncreasing studies have demonstrated potential disproportionate functional and ecological contributions of rare taxa in a microbial...
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Proteomics of Cellular Response to Stress: Taking Control of False Positive Results
AbstractOne of the main goals of quantitative proteomics is molecular profiling of cellular response to stress at the protein level. To perform this...
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False discovery rate estimation using candidate peptides for each spectrum
BackgroundFalse discovery rate (FDR) estimation is very important in proteomics. The target-decoy strategy (TDS), which is often used for FDR...
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Semantic segmentation of plant roots from RGB (mini-) rhizotron images—generalisation potential and false positives of established methods and advanced deep-learning models
BackgroundManual analysis of (mini-)rhizotron (MR) images is tedious. Several methods have been proposed for semantic root segmentation based on...
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MAST (Movement Analysis Software for Telemetry data), for the semi-automated removal of false positives from radio telemetry data
IntroductionRadio telemetry, one of the most widely used techniques for tracking wildlife and fisheries populations, has a false-positive problem....
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Course Unit 7: Promoting Positive Feelings
Emotions have a strong influence on decisions and motivation. Therefore, it is important to master the regulation of emotions. Mindfulness helps in...
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Current RT-qPCR to detect SARS-CoV-2 may give positive results for related coronaviruses
Some weeks after the first CoVID-19 outbreak, the World Health Organization published some real-time PCR (qPCR) protocols developed by different...
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Critical Thinking Identifies Misconceptions and False Trails
Many misconceptions that have compromised recognition of disease are exposed. The term porosityPorosities has been applied to so many externally...
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Detecting and correcting false transients in calcium imaging
Population recordings of calcium activity are a major source of insight into neural function. Large datasets require automated processing, but this...
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Does the fundamental host range of Trissolcus japonicus match its realized host range in Europe?
Unintentional introduction of natural enemies has increased in recent years due to a massive rise in global trade and tourism. One such natural enemy...
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Diabetes Mellitus Type 2 as a Risk Factor and Outcome Modifier for Cryptococcosis in HIV Negative, Non-transplant Patients, a Propensity Score Match Analysis
Cryptococcosis is an opportunistic fungal infection of worldwide distribution with significant associated morbidity and mortality. HIV, organ...
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Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value
Where sufficiently large genome-wide association study (GWAS) samples are not currently available or feasible, methods that leverage increasing...
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A Whole Earth Approach to Nature-Positive Food: Biodiversity and Agriculture
Agriculture is the largest single source of environmental degradation, responsible for over 30% of global greenhouse gas (GHG) emissions, 70% of...
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Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo
During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo...
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Multi-omics insights into the positive role of strigolactone perception in barley drought response
BackgroundDrought is a major environmental stress that affects crop productivity worldwide. Although previous research demonstrated links between...
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Unraveling the Positive Effect of Soil Moisture on the Bioaugmentation of Petroleum-Contaminated Soil Using Bioinformatics
Petroleum contamination is a severe threat to the soil environment. Previous studies have demonstrated that petroleum degradation efficiency is...
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A novel nanobody as therapeutics target for EGFR-positive colorectal cancer therapy: exploring the effects of the nanobody on SW480 cells using proteomics approach
BackgroundThe epidermal growth factor receptor (EGFR) overexpression is found in metastatic colorectal cancer (mCRC). Targeted molecular therapies...
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Benchmarking datasets for assembly-based variant calling using high-fidelity long reads
BackgroundRecent advances in long-read sequencing technologies have enabled accurate identification of all genetic variants in individuals or cells;...
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A Guide and Mini-Review on the Performance Evaluation Metrics in Binary Segmentation of Magnetic Resonance Images
Eight previously proposed segmentation evaluation metrics for brain magnetic resonance images (MRI), which are sensitivity (SE), specificity (SP),...