Search
Search Results
-
Clipper: p-value-free FDR control on high-throughput data from two conditions
High-throughput biological data analysis commonly involves identifying features such as genes, genomic regions, and proteins, whose values differ...
-
Unveiling the Links Between Peptide Identification and Differential Analysis FDR Controls by Means of a Practical Introduction to Knockoff Filters
In proteomic differential analysis, FDR control is often performed through a multiple test correction (i.e., the adjustment of the original...
-
Control of false discoveries in grouped hypothesis testing for eQTL data
BackgroundExpression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes....
-
Simultaneous Control of False Discovery Rate and Sensitivity Using Least Angle Regressions in High-Dimensional Data Analysis
Controlling the false discovery rate (FDR) and maintaining the high sensitivity are key desiderata in post-selection inference in high-dimensional...
-
Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study
BackgroundAspiration pneumonia (AP), which is a major cause of death in the elderly, does present with typical symptoms in the early stages of onset,...
-
Statistical Analysis of Proteomic Data Methods and Tools
This book explores the most important processing steps of proteomics data analysis and presents practical guidelines, as well as software tools, that...
-
ER-associated RNA silencing promotes ER quality control
The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. ER-associated degradation (ERAD)...
-
Direct inference and control of genetic population structure from RNA sequencing data
RNAseq data can be used to infer genetic variants, yet its use for estimating genetic population structure remains underexplored. Here, we construct...
-
TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection
A polymorphism causing deficiencies in Toll-interacting protein (TOLLIP), an inhibitory adaptor protein affecting endosomal trafficking, is...
-
Generalized precursor prediction boosts identification rates and accuracy in mass spectrometry based proteomics
Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers....
-
Grace-AKO: a novel and stable knockoff filter for variable selection incorporating gene network structures
MotivationVariable selection is a common statistical approach to identifying genes associated with clinical outcomes of scientific interest. There...
-
Combining exercise with cognitive training and vitamin D3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial
Changes in functional brain connectivity (FBC) may indicate how lifestyle modifications can prevent the progression to dementia; FBC identifies areas...
-
The rete mirabile: a possible control site for swimbladder function
In a recent study, a large number of transport proteins was detected in the transcriptome and proteome of saline perfused rete mirabile tissue of the...
-
Functional divergence of FTL9 and FTL10 in flowering control in rice
BackgroundFloral transition in cereals is a critical phenomenon influenced by exogenous and endogenous signals, determining crop yield and...
-
NeoMS: Identification of Novel MHC-I Peptides with Tandem Mass Spectrometry
The study of immunopeptidomics requires the identification of both regular and mutated MHC-I peptides from mass spectrometry data. For the efficient...
-
The causal relationship between human blood metabolites and the risk of visceral obesity: a mendelian randomization analysis
BackgroundWe aimed to explore the causal relationship between blood metabolites and the risk of visceral obesity, as measured by visceral adipose...
-
Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control
Engineered transactivation domains (TADs) combined with programmable DNA binding platforms have revolutionized synthetic transcriptional control....
-
Inflammatory monocytes promote granuloma control of Yersinia infection
Granulomas are organized immune cell aggregates formed in response to chronic infection or antigen persistence. The bacterial pathogen Yersinia pseudotuberculosis...
-
Unlocking the genetic control of spring wheat kernel traits under normal and heavy metals stress conditions
Background and aimsPb and Sn concentration increase rapidly due to the industrial revolution and cause a significant reduction in wheat production...
-
Assessing Colorectal Cancer Susceptibility in Kashmir, India: Insights from Xenobiotic Metabolism Gene Variants and Family Cancer History—A Comprehensive Case–Control Study
A family history of cancer(FHC) is a known risk factor for CRC with both genetic and other factors. A case–control study was conducted to assess the...
