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Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Existing methods for gene regulatory network (GRN) inference rely on gene expression data alone or on lower resolution bulk data. Despite the recent...
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Plant Cell Cycle: Molecular Events, Regulation by External Factors and Phytohormones
AbstractThis lecture presents classical information and new data on the molecular events of the “basic” (core) cell cycle (CC) of plants. The impact...
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From Cell States to Cell Fates: Control of Cell State Transitions
We examine the coordinated behavior of thousands of genes in cell fate transitions through genome expression as an integrated dynamical system using...
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External Liver-Derived Complement and Intrinsic Present in Hematopoietic Stem/Progenitor Cells Complosome Modulate Cell Metabolism and Response to Stress
Hematopoietic stem/progenitor cells (HSPCs) express receptors for complement cascade (ComC) cleavage fragments C3a and C5a and may respond to...
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Internal and external normalization of nascent RNA sequencing run-on experiments
In experiments with significant perturbations to transcription, nascent RNA sequencing protocols are dependent on external spike-ins for reliable...
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Inducible Pluripotent Suspension Cell Cultures (iPSCs) to Study Plant Cell Differentiation
Inducing the differentiation of specific cell type(s) synchronously and on-demand is a great experimental system to understand the sequential...
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Internal and external spectral light conversion amplifying growth/bio-products formation of Dunaliella salina
Rhodamine-6-G (R6G) was used to investigate the effect of internal/external light conversion on Dunaliella salina in a 1000 mL double-layer flat...
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Cell-Materials Interaction
Cells are able to respond to different physicochemical stimuli due to a complex molecular system that governs that response. The cell response to...
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Amplitude response and singularity behavior of circadian clock to external stimuli
Amplitude changes caused by environmental cues are universal in the circadian clock and associated with various diseases. Singularity behavior,...
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Cell Death in Photoautotrophs
Programmed cell death (PCD) is a genetically controlled mechanism regulating cellular demise. Though commonly associated with multicellular...
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Understanding Cell Differentiation Through Single-Cell Approaches: Conceptual Challenges of the Systemic Approach
The cells of a multicellular organism are derived from a single zygote and genetically almost identical. Yet, they are phenotypically very different....
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Endocytic Uptake of Nutrients, Cell Wall Molecules and Fluidized Cell Wall Portions into Heterotrophic Plant Cells
After arrival at the surface of heterotrophic cells, nutrients are taken up by these cells via endocytosis to sustain metabolic processes. Recent...
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Interaction Between Macrophages and Cryptococcus neoformans: Distinguishing Phagocytosed Versus External Fungi
The interaction between macrophages and Cryptococcus neoformans is crucial in the pathogenesis of cryptococcosis. These phagocytes are important...
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Single-Cell Quantification of the Mechanical Stability of Cell–Cell Adherens Junction Using Glass Micropipettes
Micropipette-based methods have been widely used for the manipulation of cells and characterization of the mechanical properties at the cell or...
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Stem Cell Culture Techniques
Stem cell culture is a crucial cell culture technique that involves diverse disciplines such as modern biotechnology. It is mainly used in the area...
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Mechanisms of Cell Fusion in Cancer
Cell–cell fusion is a normal physiological mechanism that requires a well-orchestrated regulation of intracellular and extracellular factors....
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Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
BackgroundSingle-cell RNA-sequencing (scRNA-seq) technologies enable the capture of gene expression heterogeneity and consequently facilitate the...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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DNA methylation-based estimators of telomere length show low correspondence with paternal age at conception and other measures of external validity of telomere length
In humans, DNA methylation (DNAm) based estimators of telomere length (TL) have been shown to better predict TL-associated variables (e.g., age, sex,...
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Ab initio protein structure prediction: the necessary presence of external force field as it is delivered by Hsp40 chaperone
BackgroundThe aqueous environment directs the protein folding process towards the generation of micelle-type structures, which results in the...
