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Simultaneous sequencing of genetic and epigenetic bases in DNA
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA...
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Quantifying the stochastic component of epigenetic aging
DNA methylation clocks can accurately estimate chronological age and, to some extent, also biological age, yet the process by which age-associated...
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Harnessing CRISPR-Cas9 for Epigenetic Engineering
Epigenome editing has become more precise and effective by coupling epigenetic effectors to the dCas9 protein and targeting regulatory regions such...
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Causality-enriched epigenetic age uncouples damage and adaptation
Machine learning models based on DNA methylation data can predict biological age but often lack causal insights. By harnessing large-scale genetic...
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Laboratory Methods in Epigenetic Epidemiology
The field of Epidemiology aims to pinpoint the risk factors for disease and health conditions and to quantify the association between...
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Profiling the Epigenetic Landscape of the Spermatogonial Stem Cell—Part 1: Epigenomics Assays
Epigenomics encompasses analyses of a variety of different epigenetic parameters which, collectively, make up the epigenetic programming that...
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Causal association of obesity with epigenetic aging and telomere length: a bidirectional mendelian randomization study
BackgroundIn observational studies, there exists an association between obesity and epigenetic age as well as telomere length. However, varying and...
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Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
BackgroundRegulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for...
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Unravelling epigenetic mechanisms in Cerastoderma edule genome: a comparison of healthy and neoplastic cockles
Cancer is a multifaceted genetic disease characterized by the acquisition of several essential hallmarks. Notably, certain cancers exhibit horizontal...
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Epigenetic clock in the aorta and age-related endothelial dysfunction in mice
While epigenetic age (EA) of mouse blood can be determined using DNA methylation analysis at three CpG sites in the Prima1 , Hsf4 and Kcns1 genes it...
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Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2...
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Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging
The decline in stem cell function during aging may affect the regenerative capacity of mammalian organisms; however, the gene regulatory mechanism...
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EpiTy**: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq
Human pluripotent stem cells (hPSCs) hold a central role in studying human development, in disease modeling and in regenerative medicine. These cells...
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Profiling the Epigenetic Landscape of the Spermatogonial Stem Cell: Part 2—Computational Analysis of Epigenomics Data
The final data-generation step of genome-wide profiling of any epigenetic parameter typically involves DNA deep sequencing which yields large...
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The Utility of Twins for Epigenetic Analysis
Twin studies have played an important role in our understanding of individual variation for over a century. The strength of these lies in the...
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The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations
With recent rapid progress in research on aging, there is increasing evidence that many features commonly considered to be mechanisms or drivers of...
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Exploring the potential of epigenetic chemicals to increase metabolite production in the dinoflagellate microalga Amphidinium carterae
This study explores the use of chemical epigenetic modifiers to enhance the production of bioactive molecules in the dinoflagellate Amphidinium...
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A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show...
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Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus
Genome sequencing has identified hundreds of histone post-translational modifications (PTMs) that define an open or compact chromatin nanostructure...
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Does epigenetic markers of HLA gene show association with coronary artery disease in Indian subjects?
BackgroundDNA methylation, one of the most stable forms of epigenetic modification is associated with the development and progression of coronary...
