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Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation
Dysregulation of the ubiquitin-proteasome system has been implicated in the pathogenesis of several metabolic disorders, including obesity, diabetes,...
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Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma
Malignant melanoma, the most aggressive form of skin cancer, is often incurable once metastatic dissemination of cancer cells to distant organs has...
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Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway
Renal fibrosis is the common final pathway in many renal diseases regardless of the underlying etiology. Adipocyte enhancer-binding protein 1 (AEBP1)...
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The interleukin enhancer binding factor-2 (ILF2) gene in Penaeus japonicus shrimp: cloning, tissue distribution, and antiviral effects
It is reported that ILF2 (interleukin enhancer binding factor 2) is involved in the immune response by regulating the transcription of interleukin 2 (
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A novel tumour enhancer function of Insulin-like growth factor II mRNA-binding protein 3 in colorectal cancer
CRC cells evolve a variety of strategies to limit or circumvent apoptosis cell death. RNA binding proteins (RBPs) regulate many of the molecular...
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CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma
Glioblastoma (GBM) is the most aggressive brain tumor and relapses after chemo- or radiotherapy in a short time. The anticancer drug temozolamide...
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Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the formation of chromatin loops and topologically associating...
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The unfolded protein response unfolds
As a key organelle of protein targeting and secretion, the endoplasmic reticulum (ER) plays host to a wide variety of protein maturation steps...
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Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol
Heparin-binding protein 17 (HBp17), first purified in 1991 from the conditioned medium of the human A431 squamous cell carcinoma (SCC) cell line, was...
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In Situ Hybridization as a Method to Examine Gene Regulatory Activity In Vivo
Transcription factor-enhancer binding events are among the most well-studied protein-DNA interactions, allowing researchers to determine mechanisms...
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Protein–Protein Interactions in Neurodegenerative Diseases
Neurodegeneration is a state of progressive decay of neuronal structure and function. It has gained scientific attention owing to the fact that...
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Enhancer Activation by Transcription Factors and Underlying Mechanisms
Enhancers are classified into two classes based on various criteria. Class I enhancersClass I enhancers participate primarily in finely tuned...
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Zygocin – a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii
Zygocin, a protein toxin secreted by virus-infected strains of the osmotolerant spoilage yeast Zygosaccharomyces bailii kills a broad spectrum of...
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Small-Molecule Inhibitors of Protein–Protein Interactions as Therapeutics
Protein–protein interactions (PPIs) have been sought as putative therapeutic targets for the advancement of various new treatments. This chapter...
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The Role of CTCF-Mediated Chromatin Loo** in Enhancer-Promoter Communication
In vertebrates, gene transcription is performed by generic eukaryotic molecular machinery under influence of sequence-specific DNA-binding...
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APEX2-Mediated Proximity Protein Labeling in Dictyostelium
Largely due to its simplicity, while being more like human cells compared to other experimental models, Dictyostelium continues to be of great use to...
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Utilization of L-glutamate as a preferred or sole nutrient in Pseudomonas aeruginosa PAO1 depends on genes encoding for the enhancer-binding protein AauR, the sigma factor RpoN and the transporter complex AatJQMP
BackgroundGlutamate and aspartate are preferred nutrients for a variety of microorganisms. In the case for many Pseudomonas spp., utilization of...
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Applications of Fungi for Alternative Protein
Fungi are among the most versatile organisms on Earth, with innovative applications in all three pillars of the emergent alternative protein...
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The Mediator complex regulates enhancer-promoter interactions
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular...
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Role of Mod(mdg4)-67.2 Protein in Interactions between Su(Hw)-Dependent Complexes and Their Recruitment to Chromatin
AbstractSu(Hw) belongs to the class of proteins that organize chromosome architecture, determine promoter activity, and participate in formation of...
