Search
Search Results
-
Porcine endogenous retrovirus: classification, molecular structure, regulation, function, and potential risk in xenotransplantation
Xenotransplantation with porcine organs has been recognized as a promising solution to alleviate the shortage of organs for human transplantation....
-
Contrasting segregation patterns among endogenous retroviruses across the koala population
Koalas ( Phascolarctos cinereus ) have experienced a history of retroviral epidemics leaving their trace as heritable endogenous retroviruses (ERVs) in...
-
The important biological roles of Syncytin-1 of human endogenous retrovirus W (HERV-W) and Syncytin-2 of HERV-FRD in the human placenta development
Background: Human endogenous retroviruses (HERVs) entered the germ line by retroviral infection from a distant ancestor over 30 million years ago and...
-
Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins
Human syncytin-1 and suppressyn are cellular proteins of retroviral origin involved in cell–cell fusion events to establish the maternal–fetal...
-
Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells
BackgroundHuman endogenous retrovirus (HERV)-K is a type of retrovirus that is present in the human genome, and its expression is usually silenced in...
-
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient retroviral infections. These...
-
Effect of human endogenous retrovirus-K env gene knockout on proliferation of ovarian cancer cells
BackgroundAmong various human endogenous retroviruses (HERVs), the HERV-K (HML-2) group has been reported to be highly related to cancer. In...
-
Insertion of an endogenous Jaagsiekte sheep retrovirus element into the BCO2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in Norwegian Spælsau (Ovis aries)
BackgroundThe accumulation of carotenoids in adipose tissue leading to yellow fat is, in sheep, a heritable recessive trait that can be attributed to...
-
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans
Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral...
-
Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance
Human endogenous retrovirus (HERVs), originating from exogenous retroviral infections of germ cells millions of years ago, have the potential for...
-
Ribosomal profiling of human endogenous retroviruses in healthy tissues
Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the...
-
-
Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts
The high abundance of most viruses in infected host cells benefits their structural characterization. However, endogenous viruses are present in low...
-
CRISPR/Cas9-mediated gene knockout and interallelic gene conversion in human induced pluripotent stem cells using non-integrative bacteriophage-chimeric retrovirus-like particles
BackgroundThe application of CRISPR/Cas9 technology in human induced pluripotent stem cells (hiPSC) holds tremendous potential for basic research and...
-
Regulation of human trophoblast gene expression by endogenous retroviruses
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving...
-
Do the Biological Roles of Endogenous and Lysogenous Viruses Represent Faustian Bargains?
Genetic transference between a host species and its viruses results in development of a collective genome which has fluidity and influences...
-
-
Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression
Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of...
