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Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles
AbstractProton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton...
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Substituted Thiazole Derivatives Provide Corrective Anti-tumour and Anti-oxidant Activities against Ehrlich Ascites Carcinoma
AbstractNovel and effective treatments are urgently needed for cancer, which is still the leading cause of death in the world. Biological...
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Scorpion Venom Peptide Smp24 Revealed Apoptotic and Antiangiogenic Activities in Solid-Ehrlich Carcinoma Bearing Mice
Scorpion venom contains various peptides that could be utilized to treat various diseases, including cancer. This study aimed to evaluate the...
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Anti-tumor Effect of High Doses of Carbon Ions and X-Rays during Irradiation of Ehrlich Ascites Carcinoma Cells Ex Vivo
AbstractThe effect of carbon ions ( 12 C) with the energy of 400 MeV/nucleon on the dynamics of induction and growth rate of solid tumors in mice...
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Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice
BackgroundPlant-derived phytochemicals have been reported to exert anticancer activity. This study investigated the antitumor role of silymarin ( Sily...
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Tissue Distribution, Histopathological and Genotoxic Effects of Magnetite Nanoparticles on Ehrlich Solid Carcinoma
Nanoparticles can potentially cause adverse effects on cellular and molecular level. The present study aimed to investigate the histopathological...
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Growth Induction of Solid Ehrlich Ascitic Carcinoma in Mice after Proton Irradiation of Tumor Cells Ex Vivo
AbstractThis study presents data on the growth rate and frequency of induction of the solid form of Ehrlich’s ascites carcinoma (EAC) in mice in the...
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Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs
BackgroundNuclear factor-κB (NF-κB) has been identified as the major link between inflammation and cancer. Natural agents that inhibit this pathway...
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An Unusual Pathway of Mitoptosis Found in Ehrlich Carcinoma Cells
AbstractAn integrated microscopic study of the destruction of mouse Ehrlich ascites carcinoma (EAC) cells under starvation conditions has been...
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Combined Effect of Neutron and Proton Radiations on the Growth of Solid Ehrlich Ascites Carcinoma and Remote Effects in Mice
AbstractThe combined effect of the irradiation with a proton pencil scanning beam (PBS) at a total dose of 80 Gy and neutron radiation at a dose of 5...
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Chrysin Encapsulated Copper Nanoparticles with Low Dose of Gamma Radiation Elicit Tumor Cell Death Through p38 MAPK/NF-κB Pathways
Improving radiation effect on tumor cells using radiosensitizers is gaining traction for improving chemoradiotherapy. This study aimed to evaluate...
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Comprehensive investigations of 2-phenylethanol production by the filamentous fungus Annulohypoxylon stygium
Abstract2-Phenylethanol (2-PE) is an aromatic compound with a rose-like fragrance that is widely used in food and other industries. Yeasts have been...
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RT-qPCR based quantitative analysis of ARO and ADH genes in Saccharomyces cerevisiae and Metschnikowia pulcherrima strains growth white grape juice
BackgroundYeast biosynthesizes fusel alcohols in fermentation through amino acid catabolism via the Ehrlich pathway. ARO8 and ARO9 genes are...
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Lippia sidoides essential oil (Verbenaceae) improves inflammatory response and histological condition in Danio rerio
This study evaluated the effect of Lippia sidoides essential oil (LSEO), at a concentration of 0.25%, on the inflammatory response and histological...
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Spotlight: Die Regulation von Arzneimitteln für neuartige Therapien (ATMP) – Rahmen und Unterstützung für die Entwicklung sicherer und wirksamer ATMP
Das Paul-Ehrlich-Institut (PEI) ist als Bundesoberbehörde zuständig für Impfstoffe und biomedizinische Arzneimittel wie z. B. monoklonale Antikörper,...
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Accumulation Dynamics of a Photosensitizer Liposomal Borated Chlorine e6 in Various Morphological Types of Experimental Tumors
AbstractPhotodynamic therapy (PDT) is an effective method for treatment of superficial malignant tumors. Determination of the time interval between...
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Green tea ameliorates the side effects of the silver nanoparticles treatment of Ehrlich ascites tumor in mice
BackgroundSilver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert...
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Rapamycin enhanced the production of 2-phenylethanol during whole-cell bioconversion by yeast
Abstract2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, has been widely utilized in food, perfume, and beverages. Saccharomyces...
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Molecular Docking and In Vivo Biological Studies of Sodium Salt of 3-(4-Methyl-2-oxo-2-H-quinoline-7-yloxy)-3-phenylacrylic Acid As Anticancer Agent
AbstractQuinoline derivatives possess several therapeutic properties. Aim: studying the anticancer effect of...
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Oxidative stress-mediated cytotoxicity of Endosulfan is causally linked to the inhibition of NADH dehydrogenase and Na+, K+-ATPase in Ehrlich ascites tumor cells
Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decreased antioxidant defense is implicated in the...
