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Tubacin Histone Deacetylase 6 Inhibitor Produced α-Tubulin Acetylation, Cell Cycle Arrest, Aging, and Suppression of Migration of Mouse Fibroblasts Transformed by E1A and cHa-ras Oncogenes
AbstractInhibitors of histone
- deacetylase activity are widely used to block cancer cell proliferation in clinical trials in vivo and in experiments...
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Conformational buffering underlies functional selection in intrinsically disordered protein regions
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms...
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E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2
Expression of the adenovirus E1A oncogene sensitizes tumor cells to innate immune rejection by NK cells. This increased NK sensitivity is only partly...
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EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer
Lobaplatin shows antitumor activity against a wide range of tumors, including triple-negative breast cancer (TNBC), and has been linked to cancer...
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Histone Deacetylase HDAC6 Inhibitor CAY10603 Blocks G1/S of the Cell Cycle and Promotes Senescence of Murine Fibroblasts Transformed with E1A and cHa-ras Oncogenes
AbstractCAY10603 (CAY) is an effective inhibitor of HDAC6 histone deacetylase involved in α-tubulin deacetylation for murine fibroblasts transformed...
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C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling
Previous studies have demonstrated that the C-terminal of E1A binding proteins (CtBPs) influences tumorigenesis by participating in cell signal...
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Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy
Oncolytic viruses are being tested in clinical trials, including in women with ovarian cancer. We use a drug-repurposing approach to identify...
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Genomic Evolution and Recombination Dynamics of Human Adenovirus D Species: Insights from Comprehensive Bioinformatic Analysis
Human adenoviruses (HAdVs) can infect various epithelial mucosal cells, ultimately causing different symptoms in infected organ systems. With more...
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PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis
Expression of the adenovirus E1A oncogene sensitizes tumor cells to innate immune rejection by apoptosis induced by macrophage-produced tumor...
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Structural biases in disordered proteins are prevalent in the cell
Intrinsically disordered proteins and protein regions (IDPs) are prevalent in all proteomes and are essential to cellular function. Unlike folded...
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Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells
BackgroundGlioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination...
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Targeted Replacement of HSF1 Phosphorylation Sites at S303/S307 with Alanine Residues in Mice Increases Cell Proliferation and Drug Resistance
Mammalian heat shock factor HSF1 transcriptional activity is controlled by a multitude of phosphorylations that occur under physiological conditions...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Restricting epigenetic activity promotes the reprogramming of transformed cells to pluripotency in a line-specific manner
Somatic cell reprogramming and oncogenic transformation share surprisingly similar features, yet transformed cells are resistant to reprogramming....
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Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids
BackgroundMitochondrial dysfunction is involved in several diseases ranging from genetic mitochondrial disorders to chronic metabolic diseases. An...
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Genetic characterization of domestic pigs in the core zone of swine production of Argentina
Argentina is a small player in the global pork market, contributing only 0.7% of the total production. With increasing global demand for meat, there...
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Kinetic Analysis of Plant SUMO Conjugation Machinery
Plant SUMO conjugation is an essential posttranslational modification involved in plant development and responses to environmental stress. Most...
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Revolutionizing Veterinary Health with Viral Vector-Based Vaccines
Vaccines signify one of the economical and reasonable means to prevent and eradicate the important infectious diseases. Conventional vaccines like...
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Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems
AbstractRecombinant adeno-associated virus (rAAV) is a major gene delivery vehicle. We have constructed a stable rAAV producer cell line by...
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Plasmide, Viren, Viroide und Prionen
Das Genom eines Organismus enthält viele DNA-Segmente, die durch Viren oder Plasmide innerhalb eines Chromosoms aber auch zwischen Chromosomen...