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Transcriptional regulation of autophagy and its implications in human disease
Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell homeostasis and promoting cell survival under stressful...
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Transcriptional and Post-transcriptional Regulation of Tuberization in Potato (Solanum tuberosum L.)
The transition from juvenile to adult stage is an important switch in the plant’s life cycle. Potato is a temperate staple food crop consumed...
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CBX4 plays a bidirectional role in transcriptional regulation and lung adenocarcinoma progression
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide. Understanding the dysregulated epigenetics governing LUAD...
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Transcriptional regulation of tomato fruit ripening
An intrinsic and genetically determined ripening program of tomato fruits often depends upon the appropriate activation of tissue- and stage-specific...
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Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
The transcriptional regulation of skeletal muscle (SKM) development (myogenesis) has been documented for over 3 decades and served as a paradigm for...
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Functions of HP1 proteins in transcriptional regulation
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the...
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The dual role of mesenchymal stem cells in apoptosis regulation
Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful immunomodulatory capacity. MSCs transplantation therapy...
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Deciphering the transcriptional regulation of the catabolism of lignin-derived aromatics in Rhodococcus opacus PD630
Rhodococcus opacus PD630 has considerable potential as a platform for valorizing lignin due to its innate “biological funneling” pathways. However,...
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Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1
Although iron overload is closely related to the occurrence of type 2 diabetes mellitus (T2DM), the specific mechanism is unclear. Here, we found...
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Transcriptional regulation and alternative splicing reveal the molecular strategies of Bombay duck Harpadon nehereus to hypoxia
Bombay duck Harpodon nehereus has undergone a dramatic shift from a by-catch fish species to the dominant species in the southeast coast of China....
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GmWRKY17-mediated transcriptional regulation of GmDREB1D and GmABA2 controls drought tolerance in soybean
Drought affects soybean growth and ultimately led to yield reduction. WRKY transcription factors involve in the regulation of abiotic stress. Few...
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LINC02015 modulates the cell proliferation and apoptosis of aortic vascular smooth muscle cells by transcriptional regulation and protein interaction network
Long intergenic nonprotein coding RNA 2015 (LINC02015) is a long non-coding RNA that has been found elevated in various cell proliferation-related...
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Anthocyanins identification and transcriptional regulation of anthocyanin biosynthesis in purple Brassica napus
Key messageThe main anthocyanin components were identified, and the transcriptional regulation pattern of anthocyanin related genes in leaves and...
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Neuropathic pain development following nerve injury is mediated by SOX11-ARID1A-SOCS3 transcriptional regulation in the spinal cord
BackgroundNeuropathic pain, a complex condition originating from nervous system damage, remains a significant clinical challenge due to limited...
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The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes
Transcription factors directly regulate gene expression by recognizing and binding to specific DNA sequences, involving the dynamic alterations of...
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Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1
Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis...
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Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)
The rapid evolution of resistance in agricultural pest poses a serious threat to global food security. However, the mechanisms of resistance through...
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Surveying the global landscape of post-transcriptional regulators
Numerous proteins regulate gene expression by modulating mRNA translation and decay. To uncover the full scope of these post-transcriptional...
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Transcriptional Regulation of Biotic and Abiotic Stress Responses: Challenges and Potential Mechanism for Stress Tolerance and Chickpea Improvement
The abiotic stress factors associated with climate change frequently enhance the severity of plant diseases, which have a detrimental impact on the...
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3D organization of regulatory elements for transcriptional regulation in Arabidopsis
BackgroundAlthough spatial organization of compartments and topologically associating domains at large scale is relatively well studied, the spatial...
