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Characterizing phenotypic data of Peromyscus leucopus compared to C57BL/6J Mus musculus and diversity outbred (DO) Mus musculus
Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we...
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Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus
BackgroundOrthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant...
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Longitudinal fragility phenoty** contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these...
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An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice
Type 2 diabetes (T2D) is a complex metabolic disorder with no cure and high morbidity. Exposure to inorganic arsenic (iAs), a ubiquitous...
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Phenoty** spontaneous locomotor activity in inbred and outbred mouse strains by using Digital Ventilated Cages
Mouse strains differ markedly in all behaviors, independently of their genetic background. We undertook this study to disentangle the diurnal...
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Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)
Purpose of ReviewMalicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed...
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Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice
Developments in long-term space exploration necessitate advancements in countermeasures against microgravity-induced skeletal muscle loss. Astronaut...
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Hybridisation and genomic diversity in British and Irish pigeons Columba livia
Human introductions of animals and plants have caused a diverse array of conservation problems, including extinction by hybridisation. This results...
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Resilience, plasticity and robustness in gene expression during aging in the brain of outbred deer mice
BackgroundGenes that belong to the same network are frequently co-expressed, but collectively, how the coordination of the whole transcriptome is...
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Emerging patterns of genetic diversity in the critically endangered Malayan tiger (Panthera tigris jacksoni)
Southeast Asia experiences some of the highest deforestation in the world. Loss of tropical forest typically leads to widespread habitat...
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Genome-wide diversity, population structure and signatures of inbreeding in the African buffalo in Mozambique
The African buffalo, Syncerus caffer , is a key species in African ecosystems. Like other large herbivores, it plays a fundamental role in its habitat...
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Crop Improvement Through Induced Genetic Diversity and Mutation Breeding: Challenges and Opportunities
Spontaneous and induced mutations form the bases for genetic diversity and evolution. Induced mutations in plants have been successfully used for the...
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Huchen Hucho hucho (Linnaeus, 1758) in Croatia: Distribution, Genetic Diversity, Threats and Conservation
Huchen Hucho hucho (L.) is one of the largest salmonids in the world and one of the most endangered fish species inhabiting the Danube River Basin in...
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Genetic analysis of global faba bean diversity, agronomic traits and selection signatures
Key messageWe identified marker-trait associations for key faba bean agronomic traits and genomic signatures of selection within a global germplasm...
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Maximizing Genetic Diversity in Coral Restoration Projects
As natural coral populations decline, thousands of outplanted corals are poised to dominate reefs in the hardest-hit areas, such as the Florida Keys....
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Inbreeding affects juvenile shoaling behaviour in sibling groups of a cichlid fish
Whilst the effects of inbreeding on growth and survival have been well studied, knowledge on the impact of inbreeding on the social behaviour is...
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Diversity and structure of Bettongia tropica: using population genetics to guide reintroduction and help prevent the extinction of an endangered Australian marsupial
Conservation translocations can restore populations and prevent extinction of threatened species. Sourcing adequate genetic diversity is an essential...
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Genomic evidence that a sexually selected trait captures genome-wide variation and facilitates the purging of genetic load
The evolution of costly traits such as deer antlers and peacock trains, which drove the formation of Darwinian sexual selection theory, has been...
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The Genetic Diversity and Structure of an Isolated Population from Northern European Russia Based on Whole-Exome Sequencing Data
AbstractThis study reports the results of the analysis of exome variations in an isolated rural population from northern European Russia. Initially a...
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Effects of inbreeding on fertilization, growth and survival in the tetraploid Pacific oyster Crassostrea gigas
Induced homologous tetraploid oysters are typically derived from a limited number of effective parents, with subsequent breeding steps likely to...
