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Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy
PurposeOxidative stress in chronic hyperglycemia could injure the tissues and onset of diabetes-related complications like retinopathy and...
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Therapeutic Effect of Schwann Cell-Like Cells Differentiated from Human Tonsil-Derived Mesenchymal Stem Cells on Diabetic Neuropathy in db/db Mice
Background:Diabetic neuropathy (DN) is the most common complication of diabetes, and approximately 50% of patients with this disease suffer from...
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Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review
Diabetic neuropathy is one of the most prevalent chronic complications of diabetes, and up to half of diabetic patients will develop diabetic...
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The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
BackgroundIncreased levels of low-density lipoprotein cholesterol (LDL-C) have been identified as one potential risk factor for diabetic peripheral...
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Sphingolipid metabolism plays a key role in diabetic peripheral neuropathy
IntroductionAs the most common chronic complication of diabetes mellitus (DM), diabetic peripheral neuropathy (DPN) seriously affects the quality of...
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Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
Diabetic neuropathy is an incurable disease. We previously identified a mechanism by which aberrant bone marrow-derived cells (BMDCs) pathologically...
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PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3
Diabetic peripheral neuropathy (DPN) is a frequently occurring chronic complication of diabetes. In this study, we aim to explore the regulatory...
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Gut microbiota in relationship to diabetes mellitus and its late complications with a focus on diabetic foot syndrome: A review
Diabetes mellitus is a chronic disease affecting glucose metabolism. The pathophysiological reactions underpinning the disease can lead to the...
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Therapeutic potential of Nrf-2 pathway in the treatment of diabetic neuropathy and nephropathy
Type 2 diabetes (T2D) is one of the most widely spread metabolic disordersand is also referred as a ‘lifestyle’ disorder. According toa study...
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Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws
Complications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care...
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Exploring the molecular role of endostatin in diabetic neuropathy
AbstractFor over a decade, diabetic neuropathy has exhibited great emergence in diabetic patients. Though there are numerous impediments in...
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High triglyceride levels increase the risk of diabetic microvascular complications: a cross-sectional study
BackgroundThe prevalence of microvascular complications in type 2 diabetes mellitus (T2DM) is increasing. The effect of lipid profiles on diabetic...
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An association between fibrinogen gene polymorphisms and diabetic peripheral neuropathy in young patients with type 1 diabetes
In complex etiopathogenesis of diabetic peripheral neuropathy (DPN), hemostatic dysfunction and subclinical inflammation play a possible role....
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An Update on Diabetic Foot Ulcer and Its Management Modalities
One of the most prominent challenges related to the management of diabetes is a diabetic foot ulcer (DFU). It has been noted that > 50% of ulcers...
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The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy
The primary symptom of diabetic encephalopathy (DE), a kind of central diabetic neuropathy caused by diabetes mellitus (DM), is cognitive impairment....
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Farrerol Alleviates Diabetic Cardiomyopathy by Regulating AMPK-Mediated Cardiac Lipid Metabolic Pathways in Type 2 Diabetic Rats
Diabetic cardiomyopathy (DCM) is a prevalent complication of diabetes mellitus characterized by cardiac dysfunction and myocardial remodeling....
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TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM) and the dysfunction of Schwann cells plays an...
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Scaffold-based delivery of mesenchymal stromal cells to diabetic wounds
Foot ulceration is a major complication of diabetes mellitus, which results in significant human suffering and a major burden on healthcare systems....
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Role of AMP deaminase in diabetic cardiomyopathy
Diabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent...
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Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
BackgroundAn effective treatment for acute non-arteritic ischemic optic neuropathy (NA-AION) has not been known or proven yet. Previous studies have...
