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Transcriptomic landscape reveals germline potential of porcine skin-derived multipotent dermal fibroblast progenitors
According to estimations, approximately about 15% of couples worldwide suffer from infertility, in which individuals with azoospermia or oocyte...
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Murine skin-derived multipotent papillary dermal fibroblast progenitors show germline potential in vitro
BackgroundMany laboratories have described the in vitro isolation of multipotent cells with stem cell properties from the skin of various species...
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Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function
BackgroundThe function of exosomes, small extracellular vesicles (sEV) secreted from human adipose-derived stem cells (ADSC), is becoming...
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An approach for elucidating dermal fibroblast dedifferentiation in amphibian limb regeneration
Urodele amphibians, Pleurodeles waltl and Ambystoma mexicanum , have organ-level regeneration capability, such as limb regeneration. Multipotent cells...
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Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes
This article summarizes important molecular mechanisms that drive aging in human skin from the perspective of dermal fibroblasts. The dermis...
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Involvement of the PI3K/AKT Pathway in the Formation and Fusion of Spheroids Derived from Human Dermal Fibroblast for Tissue Engineering Technology
AbstractThrough the biofabrication technology using cellular aggregates (spheroids), an artificial blood vessel derived from autologous cells of...
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Huntington’s Disease Alters the Dermal Fibroblasts Secretome
AbstractHuntington’s disease is a hereditary incurable neurodegenerative disease caused by expansion of the polyglutamine tract in exon 1 of the...
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Dermal fibroblast cells interactions with single and triple bacterial-species biofilms
Polymicrobial biofilm leads to wound healing delay. We set up an in vitro co-culture model of single- and triple-species biofilms of Staphylococcus...
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Transcriptome Analysis of Human Dermal Cells Infected with Candida auris Identified Unique Pathogenesis/Defensive Mechanisms Particularly Ferroptosis
Candida auris is an emerging multi-drug resistant yeast that can cause life-threatening infections. A recent report clarified the ability of C. auris ...
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The Morphology and Ultrastructure of Dermal Telocytes Characterized by TEM and AFM
This investigation delves into the structural foundation of human dermal telocytes (TCs) with the aim of elucidating their role in signal...
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Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivascular cells, stromal progenitor cells...
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Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues
BackgroundInduced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell...
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Anti-aging effects of fetal dermal mesenchymal stem cells in a D-galactose-induced aging model of adult dermal fibroblasts
The main characteristic of skin aging is the change in the composition of the dermis, mainly resulting from fibroblast senescence. Mesenchymal stem...
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CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
Skin primarily comprises a collagen-rich extracellular matrix (ECM) that provides structural and functional support to the skin. Aging causes...
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Reprogramming fibroblast into human iBlastoids
The study of early human embryogenesis has relied on the use of blastocysts donated to research or simple stem cell culture systems such as...
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Role of fibroblast plasticity and heterogeneity in modulating angiogenesis and healing in the diabetic foot ulcer
Chronic diabetic foot ulcers (DFUs) are an important clinical issue faced by clinicians despite the advanced treatment strategies consisting of wound...
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Mangiferin, a naturally occurring polyphenol, mitigates oxidative stress induced premature senescence in human dermal fibroblast cells
Chronic oxidative stress has been associated with several human ailments including the condition of aging. Extensive studies have shown the causal...
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Endoplasmic Reticulum Stress Inducer Dithiothreitol Affects the Morphology and Motility of Cultured Human Dermal Fibroblasts and Fibrosarcoma HT1080 Cell Line
AbstractSome inducers of endoplasmic reticulum (ER) stress can affect the motility of normal and tumor cells. However, it is unknown what mechanisms...
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High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing
It is widely acknowledged that diabetes leads to slow wound healing and ulceration, and severe serious diabetic foot ulceration may result in...
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Dosage compensation of Z sex chromosome genes in avian fibroblast cells
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole...
