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Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure
Gastrulation and neurulation are successive morphogenetic processes that play key roles in sha** the basic embryonic body plan. Importantly, they...
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The role of microRNAs in diseases and related signaling pathways
MicroRNAs (miRNAs) are epigenetic regulators of the gene expression and act through posttranslational modification. They bind to 3′-UTR of target...
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TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
The complexity of intracellular signalling requires both a diversity of molecular players and the sequestration of activity to unique compartments...
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Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma
BackgroundThe purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of...
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CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis
Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF) with a multitude of clinical manifestations. Some...
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Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is...
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Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets
Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling...
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Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4
Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we...
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Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling
BackgroundThe Wnt non-canonical pathway (Wnt5a > Frizzled-2 > cyclic GMP phosphodiesterase/Ca 2+ -mobilization pathway regulates the activation of...
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Endocytic regulation of TGF-β signaling
Transforming growth factor-β (TGF-β) signaling is tightly regulated to ensure its proper physiological functions in different cells and tissues. Like...
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Networking of WNT, FGF, Notch, BMP, and Hedgehog Signaling Pathways during Carcinogenesis
The biological functions of some orthologs within the human genome and model-animal genomes are evolutionarily conserved, but those of others are...
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Nodal signals pattern vertebrate embryos
Vertebrate embryonic patterning requires several conserved inductive signals–including Nodal, Bmp, Wnt and Fgf signals. Nodal, which is a member of...