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A cytosol-tethered YHB variant of phytochrome B retains photomorphogenic signaling activity
The red and far-red light photoreceptor phytochrome B (phyB) transmits light signals following cytosol-to-nuclear translocation to regulate...
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The effect of ionic redistributions on the microwave dielectric response of cytosol water upon glucose uptake
The sensitivity of cytosol water's microwave dielectric (MD) response to D-glucose uptake in Red Blood Cells (RBCs) allows the detailed study of...
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Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer...
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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol
Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show that proteasome...
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Immunometabolic mechanisms of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, already accounting for at least half of all cases of...
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Cholera toxin: mechanisms of entry into host cells
Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Trafficking in this pathway depends on toxin binding to...
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Biochemical Fractionation of Trypanosomes for the Analysis of Glycosomal Protein Import Defects
Insect-transmitted trypanosomatid parasite infections cause life-threatening neglected tropical diseases (NTDs), including African slee** sickness,...
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Cytosolic sorting platform complexes shuttle type III secretion system effectors to the injectisome in Yersinia enterocolitica
Bacteria use type III secretion injectisomes to inject effector proteins into eukaryotic target cells. Recruitment of effectors to the machinery and...
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Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol
Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic...
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Anti-apoptotic effect of adipose tissue-derived stromal vascular fraction in denervated rat muscle
BackgroundRecovery of muscle function after peripheral nerve injury is often poor, and this can be attributed to muscle fiber atrophy and cell death....
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GRminusRD: A Sensitive Assay to Detect Activation Processes at the Plasma Membrane in Living Cells
Activation processes at the plasma membrane have been studied with life-cell imaging using GFP fused to a protein that binds to a component of the...
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Analysis of 3′-Phosphoadenosine 5′-Phosphosulfate Transporters: Transporter Activity Assay, Real-Time Reverse Transcription Polymerase Chain Reaction, and Immunohistochemistry
3′-Phosphoadenosine 5′-phosphosulfate transporters (PAPSTs) play an important role in transporting 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the...
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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into...
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System-wide analysis of RNA and protein subcellular localization dynamics
Although the subcellular dynamics of RNA and proteins are key determinants of cell homeostasis, their characterization is still challenging. Here we...
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Gradient Strategy for Mixotrophic Cultivation of Chlamydomonas reinhardtii: Small Steps, a Large Impact on Biofuel Potential and Lipid Droplet Morphology
Mixotrophic cultivation of microalgae is an economical and environment-friendly approach to benefit biofuel production by increasing biomass. In this...
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Diverse functions of cytochrome c in cell death and disease
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisions of life and death. Under normal...
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ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs
Bidirectional transcription of mammalian mitochondrial DNA generates overlap** transcripts that are capable of forming double-stranded RNA (dsRNA)...
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p40phox: Composition, Function and Consequences of Its Absence
The NOX2 protein complex in human leukocytes consists of five proteins: gp91phox (NOX2) and p22phox (together called flavocytochrome b558) embedded...
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Arabidopsis AtLTI30 and AtHIRD11 dehydrin genes and their contribution to cadmium tolerance in transgenic tobacco plants
We investigated the contribution of two Arabidopsis AtHIRD11 (AT1G54410, DH1) and AtLTI30 (AT3G50970, DH3) dehydrin genes to cadmium stress tolerance...
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MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis
Mixed lineage kinase-like protein (MLKL) forms amyloid-like polymers to promote necroptosis; however, the mechanism through which these polymers...
